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Maximal secretory capacity of somatotrope cells in obesity: comparison with GH deficiency
- Source :
- Scopus-Elsevier
- Publication Year :
- 1997
- Publisher :
- Springer Science and Business Media LLC, 1997.
-
Abstract
- OBJECTIVE: To evaluate the maximal secretory capacity of somatotrope cells in obesity and to compare it with that in hypopituitaric patients with GH deficiency. DESIGN: Stimulation with GHRH. (1 μg/kg iv) combined with arginine (ARG, 0.5 g/kg iv), which strongly potentiates the GH response to the neurohormone, likely inhibiting hypothalamic somatostatin. The reproducibility of the GH response to GHRH+ARG was evaluated in a second session. SUBJECTS: Forty-five patients with simple obesity (OB 11 male and 34 female, age 40.5±1.8 y, BMI 38.8±1.1 kg/m2), 49 patients with hypopituitarism (GHD, 23 male and 26 female, 43.6±2.4 y, 24.7±0.7 kg/m2) and 44 normal young volunteers (NS, 25 male and 19 female, 33.8±1.0 y, 21.6±0.3 kg/m2) were studied. MEASUREMENTS: GH levels were assayed by IRMA method, basally at −60 and 0 min, and than every 15 min up to +120 min. Basal IGF–I levels were assayed by RIA method, after acid-ethanol extraction. RESULTS: IGF–I levels in OB were lower (P
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Somatotropic cell
Arginine
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Stimulation
Hypopituitarism
Growth Hormone-Releasing Hormone
Pathogenesis
Basal (phylogenetics)
Internal medicine
medicine
Humans
Obesity
Nutrition and Dietetics
Human Growth Hormone
business.industry
Reproducibility of Results
Middle Aged
Growth hormone–releasing hormone
medicine.disease
Endocrinology
Somatostatin
Female
business
Subjects
Details
- ISSN :
- 14765497 and 03070565
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity
- Accession number :
- edsair.doi.dedup.....198b09f6c69f86e8a3fb9ebc2689b5e7