Back to Search
Start Over
Medications for substance use disorders (SUD): emerging approaches
- Source :
- Expert opinion on emerging drugs. 22(4)
- Publication Year :
- 2017
-
Abstract
- Substance use disorders are a group of chronic relapsing disorders of the brain, which have massive public health and societal impact. In some disorders (e.g., heroin/prescription opioid addictions) approved medications have a major long-term benefit. For other substances (e.g., cocaine, amphetamines and cannabis) there are no approved medications, and for alcohol there are approved treatments, which are not in wide usage. Approved treatments for tobacco use disorders are available, and novel medications are also under study. Areas covered: Medication-based approaches which are in advanced preclinical stages, or which have reached proof-of concept clinical laboratory studies, as well as clinical trials. Expert opinion: Current challenges involve optimizing translation between preclinical and clinical development, and between clinical laboratory studies to therapeutic clinical trials. Comorbidities including depression or anxiety are challenges for study design and analysis. Improved pharmacogenomics, biomarker and phenotyping approaches are areas of interest. Pharmacological mechanisms currently under investigation include modulation of glutamatergic, GABA, vasopressin and κ-receptor function, as well as inhibition of monoamine re-uptake. Other factors that affect potential market size for emerging medications include stigma, availability of treatment settings, adoption by clinicians, and the prevalence of persons with SUD who are not actively treatment-seeking.
- Subjects :
- medicine.medical_specialty
Substance-Related Disorders
media_common.quotation_subject
Drug Evaluation, Preclinical
Article
Heroin
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Pharmacology (medical)
Medical prescription
Psychiatry
media_common
Pharmacology
Clinical Trials as Topic
biology
business.industry
Public health
Addiction
Mental Disorders
biology.organism_classification
medicine.disease
030227 psychiatry
Substance abuse
Prescription opioid
Diagnosis, Dual (Psychiatry)
Drug Design
Cannabis
Substance use
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 17447623
- Volume :
- 22
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Expert opinion on emerging drugs
- Accession number :
- edsair.doi.dedup.....1998a50786362a21f38fc3c87dc2a2c0