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Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients
- Source :
- Journal of Psychiatric Research. 45:234-241
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- The HOMER 1 protein plays a crucial role in mediating glutamatergic neurotransmission. It has previously shown to be a candidate gene for etiology and pathophysiology of different psychiatric diseases such as schizophrenia. To identify genes involved in response to antipsychotics, subgroups of animals were treated with haloperidol (1 mg/kg, n = 11) or saline (n = 12) for one week. By analyzing microarray data, we replicated the observed increase of Homer 1 gene expression. Furthermore, we genotyped 267 schizophrenic patients, who were treated monotherapeutically with different antipsychotics within randomized-controlled trials. Psychopathology was measured weekly using the PANSS for a minimum of four and a maximum of twelve weeks. Correlations between PANSS subscale scores at baseline and PANSS improvement scores after four weeks of treatment and genotypes were calculated by using a linear model for all investigated SNP’s. We found an association between two HOMER 1 polymorphisms (rs2290639 and rs4704560) and different PANSS subscales at baseline. Furthermore all seven investigated polymorphisms were found to be associated with therapy response in terms of a significant correlation with different PANSS improvement subscores after four weeks of antipsychotic treatment. Most significant associations have been shown between the rs2290639 HOMER 1 polymorphism and PANSS subscales both at baseline conditions and after four weeks of antipsychotic treatment. This is the first study which shows an association between HOMER 1 polymorphisms and psychopathology data at baseline and therapy response in a clinical sample of schizophrenic patients. Thus, these data might further help in detecting differential therapy response in individuals with schizophrenia.
- Subjects :
- Adult
Male
Oncology
Candidate gene
medicine.medical_specialty
Genotype
Polymorphism, Single Nucleotide
Correlation
Young Adult
Gene Frequency
Homer Scaffolding Proteins
Internal medicine
Haloperidol
medicine
Animals
Humans
SNP
Rats, Long-Evans
Biological Psychiatry
Psychiatric Status Rating Scales
Psychopathology
Middle Aged
Pathophysiology
Rats
Psychiatry and Mental health
Gene Expression Regulation
Pharmacogenetics
Schizophrenia
Etiology
Female
Schizophrenic Psychology
Carrier Proteins
Psychology
Antipsychotic Agents
Genome-Wide Association Study
Clinical psychology
medicine.drug
Subjects
Details
- ISSN :
- 00223956
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Journal of Psychiatric Research
- Accession number :
- edsair.doi.dedup.....19a31777bbee1806b90d432b597bb534