Back to Search Start Over

Caregiver burden and its related factors in advanced Parkinson's disease: data from the PREDICT study

Authors :
Leonardo Lopiano
Paolo Solla
Mariachiara Sensi
Giovanni Defazio
Rocco Quatrale
Nicola Tambasco
Anna Maria Costanzo
Pietro Marano
Angelo Antonini
Umberto di Luzio Paparatti
Francesco E. Pontieri
Nicola Modugno
Alessandro Tessitore
Gabriella Melzi
Margherita Canesi
Giuliana Gualberti
Anna Latorre
Tessitore, A.
Marano, P.
Modugno, N.
Pontieri, F. E.
Tambasco, N.
Canesi, M.
Latorre, A.
Lopiano, L.
Sensi, M.
Quatrale, R.
Solla, P.
Defazio, G.
Melzi, G.
Costanzo, A. M.
Gualberti, G.
di Luzio Paparatti, U.
Antonini, A.
Source :
Journal of Neurology
Publication Year :
2017

Abstract

Introduction: Caring for a person with Parkinson’s disease (PD) is associated with an increased risk of psychiatric morbidity and persistent distress. The objective of this study was to describe the burden and the related factors of caregivers of advanced PD (APD) patients either treated with continuous dopaminergic delivery systems or standard therapy. Methods: This cross-sectional, epidemiologic study conducted in 13 Italian sites enrolled PD patients treated with continuous dopaminergic delivering systems [either levodopa/carbidopa intestinal gel (LCIG) infusion or continuous subcutaneous apomorphine infusion (CSAI)] or continuation of standard of care (SOC) with a caregiver. Patient quality of life (QoL) and caregiver burden were assessed using the Parkinson’s Disease Questionnaire (PDQ-8) and Zarit Burden Inventory (ZBI), respectively. Results: 126 patients (mean age 69.3 ± 8years) and their caregivers (mean age 57.9 ± 12.9) were enrolled. Most caregivers were spouses. Fifty-three patients were treated with LCIG, 19 with CSAI, and 54 with SOC. Mean ZBI scores were 29.6 ± 14.4 for LCIG, 35.8 ± 20.2 for CSAI, and 31.4 ± 16.0 for SOC. Caregivers of LCIG, CSAI, and SOC patients showed no burden or mild/moderate burden in 74, 53, and 63% of the cases, respectively. Mean PDQ-8 scores were 11.25 ± 5.67, 11.26 ± 5.55, and 14.22 ± 6.51 in LCIG, CSAI, and SOC patients. Neurologists considered patients “very much or much improved” in 89, 58, and 13% of the LCIG, CSAI, and SOC groups using the Clinical Global Impression–Global Improvement Scale. Predictors significantly associated with caregiver burden were patients and caregivers’ judgment of QoL and caregivers’ need to change work. Conclusions: Caregiver burden showed a tendency to be lower when patients are treated with LCIG than with CSAI or SOC.

Details

ISSN :
14321459
Volume :
265
Issue :
5
Database :
OpenAIRE
Journal :
Journal of neurology
Accession number :
edsair.doi.dedup.....19a52f256e675cb223cc9e3bdd2ecd9e