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Population-wide impacts of aspirin, statins, and metformin use on prostate cancer incidence and mortality
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- We evaluated the association between aspirin, statins, and metformin use and prostate cancer (PC) incidence and mortality using a large population-based dataset. 388,760 men who participated in national health screening program in Korea during 2002–2003 were observed from 2004 to 2013. Hazard ratios of aspirin, statins, and metformin use for PC incidence and PC mortality were calculated with adjustment for simultaneous drug use. Cumulative use of each drug was inserted as time-dependent variable with 2-year time windows. Aspirin use ≥ 1.5 year (per 2-year) was associated with borderline decrease in PC mortality when compared to non-users (adjusted hazard ratio [aHR] 0.71, 95% confidence interval [CI] 0.50–1.02). Statins use was not associated with either PC incidence or PC mortality. Metformin ever-use was associated with decreased PC incidence compared with non-diabetics (aHR 0.86, 95% CI 0.77–0.96). Diabetics who were not using metformin or using low cumulative doses had higher PC mortality than non-diabetics (aHR 2.01, 95% CI 1.44–2.81, and aHR 1.70, 95% CI 1.07–2.69, respectively). However, subjects with higher cumulative doses of metformin did not show increased PC mortality. In conclusion, metformin use was associated with lower PC incidence. Use of aspirin and that of metformin among diabetic patients were associated with lower PC mortality.
- Subjects :
- Adult
Male
medicine.medical_specialty
Epidemiology
Science
Population
Urological cancer
Gastroenterology
Article
Cancer prevention
Cohort Studies
Prostate cancer
Cancer epidemiology
Internal medicine
Republic of Korea
medicine
Humans
Hypoglycemic Agents
Longitudinal Studies
education
Prostate cancer incidence
Aged
Proportional Hazards Models
Cancer
Aged, 80 and over
Aspirin
education.field_of_study
Multidisciplinary
business.industry
Incidence
Incidence (epidemiology)
Hazard ratio
Prostatic Neoplasms
nutritional and metabolic diseases
Middle Aged
medicine.disease
Health Surveys
Metformin
Confidence interval
Medicine
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....19b9c5ec112f5eaf70ca324ba066722f