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Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murine model of peritoneal carcinomatosis
- Source :
- Journal of Experimental and Clinical Cancer Research, Journal of Experimental and Clinical Cancer Research, BioMed Central, 2011, 30 (1), pp.4. ⟨10.1186/1756-9966-30-4⟩, Journal of Experimental & Clinical Cancer Research, Vol 30, Iss 1, p 4 (2011), Journal of Experimental and Clinical Cancer Research, BioMed Central, 2011, 30 (1), pp.4. 〈10.1186/1756-9966-30-4〉, Journal of Experimental & Clinical Cancer Research : CR
- Publication Year :
- 2011
- Publisher :
- HAL CCSD, 2011.
-
Abstract
- Background The best method to deliver intraperitoneal chemotherapy (IPC) for peritoneal carcinomatosis from ovarian cancer is not well defined. The aim of this study was to assess the ability of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a rat model of peritoneal carcinomatosis. Methods Four groups of 5 BDIX rats with ovarian peritoneal carcinomatosis underwent IPC with 30 mg/l of cisplatin according to the following conditions: normothermia at 37° for 1 or 2 hours, hyperthermia at 42°C for 1 hour or normothermia at 37°C for 2 hours with 2 mg/l adrenaline. Tissue platinum content was measured by atomic absorption spectroscopy. The effect of hyperthermia, adrenaline and the duration of exposure to the drug was measured in vivo (tissue concentration of platinum in tumor, abdominal and extra abdominal tissues) and in vitro (cytotoxicity on human ovarian cancer cells). Results In vitro, hyperthermia and longer exposure enhanced the accumulation and the cytotoxic effect of cisplatin on cancer cells. In vivo, only the 2 hours treatment with adrenaline resulted in increased platinum concentrations. The rats treated with adrenaline showed significantly lower concentrations of cisplatin in extra peritoneal tissues than those treated with hyperthermia. Conclusion Adrenaline is more effective than hyperthermia in order to enhance the intratumoral concentration of cisplatin in rats with peritoneal carcinomatosis from ovarian origin. It may also decrease the systemic absorption of the drug.
- Subjects :
- MESH : Hyperthermia, Induced
MESH : Rats, Inbred Strains
Cancer Research
Pathology
Pharmacology
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
Peritoneal Neoplasm
0302 clinical medicine
MESH : Tumor Cells, Cultured
Tumor Cells, Cultured
Medicine
MESH: Peritoneal Neoplasms
MESH : Female
MESH: Animals
Peritoneal Neoplasms
Ovarian Neoplasms
MESH : Cell Survival
0303 health sciences
MESH : Rats
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
MESH: Rats, Inbred Strains
3. Good health
MESH : Antineoplastic Agents
MESH: Ovarian Neoplasms
Epinephrine
Oncology
MESH: Cell Survival
030220 oncology & carcinogenesis
Female
medicine.drug
Hyperthermia
medicine.medical_specialty
MESH: Rats
Cell Survival
MESH: Epinephrine
Antineoplastic Agents
[SDV.CAN]Life Sciences [q-bio]/Cancer
lcsh:RC254-282
MESH : Cisplatin
03 medical and health sciences
[SDV.CAN] Life Sciences [q-bio]/Cancer
MESH : Peritoneal Neoplasms
In vivo
Animals
Humans
MESH: Tumor Cells, Cultured
MESH: Hyperthermia, Induced
030304 developmental biology
Cisplatin
MESH: Humans
MESH : Ovarian Neoplasms
business.industry
Research
MESH : Humans
Rats, Inbred Strains
Hyperthermia, Induced
medicine.disease
MESH : Disease Models, Animal
Rats
Disease Models, Animal
MESH: Cisplatin
Apoptosis
MESH : Epinephrine
Cancer cell
MESH: Antineoplastic Agents
MESH : Animals
MESH: Disease Models, Animal
business
Ovarian cancer
MESH: Female
Subjects
Details
- Language :
- English
- ISSN :
- 03929078
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental and Clinical Cancer Research, Journal of Experimental and Clinical Cancer Research, BioMed Central, 2011, 30 (1), pp.4. ⟨10.1186/1756-9966-30-4⟩, Journal of Experimental & Clinical Cancer Research, Vol 30, Iss 1, p 4 (2011), Journal of Experimental and Clinical Cancer Research, BioMed Central, 2011, 30 (1), pp.4. 〈10.1186/1756-9966-30-4〉, Journal of Experimental & Clinical Cancer Research : CR
- Accession number :
- edsair.doi.dedup.....19e610db54b776770f2293156cfb525a