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Chinese herbal medicine Qinggongshoutao for the treatment of amnestic mild cognitive impairment: A 52-week randomized controlled trial
- Source :
- Alzheimer's & Dementia : Translational Research & Clinical Interventions
- Publication Year :
- 2019
-
Abstract
- Introduction This randomized, double-blind trial aimed to test effect of a Chinese herbal medicine, Qinggongshoutao (QGST) pill, on the cognition and progression of amnestic mild cognitive impairment (aMCI). Methods Patients with aMCI were randomly assigned to receive QGST, Ginkgo biloba extract, or placebo for 52 weeks. The primary outcome measures were progression to possible or probable Alzheimer's disease (AD) and change in Alzheimer's Disease Assessment Scale–cognitive subscale scores; secondary outcome measures included assessments for cognition and function. Results Total 350 patients were enrolled, possible or probable AD developed in 10. There were significant differences in the probability of progression to AD in the QGST group (1.15%) compared with placebo group (10%). There was significant difference in Alzheimer's Disease Assessment Scale–cognitive subscale scores in favor of QGST over the placebo group. Secondary outcome measure (Mini-Mental State Examination) also showed benefit in QGST at end point. Discussion In patients with aMCI, QGST showed lower AD progression rate than placebo at 8.85%, and may have benefit on global cognition.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Efficacy
Disease
Placebo
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Medicine
Cognitive impairment
biology
business.industry
Ginkgo biloba
Cognition
Featured Article
biology.organism_classification
Psychiatry and Mental health
030104 developmental biology
Pill
Secondary Outcome Measure
Amnestic mild cognitive impairment
Randomized clinical trial
Neurology (clinical)
Herbal medicine
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 23528737
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Alzheimer'sdementia (New York, N. Y.)
- Accession number :
- edsair.doi.dedup.....19f52a251c173e2de645cfdc3bd6c6dd