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Chinese herbal medicine Qinggongshoutao for the treatment of amnestic mild cognitive impairment: A 52-week randomized controlled trial

Authors :
Xiuqiao Sun
Yongyan Wang
Jingnian Ni
Lei Li
Yaming Lin
Hongjun Yao
Guangyin Xu
Kang Li
Hui Zhen
Baoshen Wang
Mingqing Wei
Jinzhou Tian
Keji Chen
Yueqiang Hu
Faming Yang
Baoai Wang
Heng Wang
Jing Shi
Jinyan Xu
Jinyu Gao
Yong Zou
Juntao Li
Likai Su
Zhiyong Fang
Min Min
Jintao Zhang
Source :
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Publication Year :
2019

Abstract

Introduction This randomized, double-blind trial aimed to test effect of a Chinese herbal medicine, Qinggongshoutao (QGST) pill, on the cognition and progression of amnestic mild cognitive impairment (aMCI). Methods Patients with aMCI were randomly assigned to receive QGST, Ginkgo biloba extract, or placebo for 52 weeks. The primary outcome measures were progression to possible or probable Alzheimer's disease (AD) and change in Alzheimer's Disease Assessment Scale–cognitive subscale scores; secondary outcome measures included assessments for cognition and function. Results Total 350 patients were enrolled, possible or probable AD developed in 10. There were significant differences in the probability of progression to AD in the QGST group (1.15%) compared with placebo group (10%). There was significant difference in Alzheimer's Disease Assessment Scale–cognitive subscale scores in favor of QGST over the placebo group. Secondary outcome measure (Mini-Mental State Examination) also showed benefit in QGST at end point. Discussion In patients with aMCI, QGST showed lower AD progression rate than placebo at 8.85%, and may have benefit on global cognition.

Details

ISSN :
23528737
Volume :
5
Database :
OpenAIRE
Journal :
Alzheimer'sdementia (New York, N. Y.)
Accession number :
edsair.doi.dedup.....19f52a251c173e2de645cfdc3bd6c6dd