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Lipoprotein metabolism in a rat model of diet-induced adiposity
- Source :
- The Journal of nutrition. 117(10)
- Publication Year :
- 1987
-
Abstract
- Obesity in humans is associated with decreased plasma levels of high density lipoprotein (HDL), but the mechanisms effecting this relationship have not been established. Four treatment groups were used to develop a range of moderate adiposity: rat pups were raised in litters of 4 or 14 and fed from weaning diets of 6 or 24% fat (wt/wt) for 15-17 wk. Lipoproteins from plasma and from a recirculating in situ liver perfusion system were then separated and analyzed, lipoprotein lipase (LPL) activity was assayed in samples of adipose tissue and skeletal muscle and body composition and cholesterol concentrations of various tissues were determined. There was little effect of the diet or litter size treatments on plasma lipids or lipoprotein profiles. Compared to the marked changes in lipid and lipoprotein metabolism that have been observed in severely obese animal models, there was generally little effect of the treatments used to produce this model of moderate diet-induced adiposity. Adiposity was unrelated to plasma total cholesterol and triglycerides. While fatness was positively, although weakly, correlated with plasma levels of several HDL components, including HDL cholesterol, there were no consistent treatment effects on these measures. Plasma HDL levels and adiposity were unrelated to hepatic HDL production or tissue LPL activities. A review of the literature suggests that differences in plasma HDL responses to adiposity in humans and in experimental animals may be due to inherent species differences in lipoprotein metabolism.
- Subjects :
- Male
medicine.medical_specialty
Litter Size
Lipoproteins
Medicine (miscellaneous)
Adipose tissue
Biology
chemistry.chemical_compound
High-density lipoprotein
Internal medicine
medicine
Weaning
Animals
Obesity
Lipoprotein lipase
Nutrition and Dietetics
Triglyceride
Cholesterol
Muscles
Rats, Inbred Strains
Metabolism
Lipid Metabolism
Dietary Fats
Lipids
Rats
Disease Models, Animal
Lipoprotein Lipase
Endocrinology
chemistry
Adipose Tissue
Liver
lipids (amino acids, peptides, and proteins)
Lipoproteins, HDL
Lipoprotein
Subjects
Details
- ISSN :
- 00223166
- Volume :
- 117
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- The Journal of nutrition
- Accession number :
- edsair.doi.dedup.....1a04227cffcd1aff4857071081173afa