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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- Source :
- Conti, D V, Darst, B F, Moss, L C, Saunders, E J, Sheng, X, Chou, A, Schumacher, F R, Olama, A A A, Benlloch, S, Dadaev, T, Brook, M N, Sahimi, A, Hoffmann, T J, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Muir, K, Lophatananon, A, Wan, P, Le Marchand, L, Wilkens, L R, Stevens, V L, Gapstur, S M, Carter, B D, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Giles, G G, Southey, M C, MacInnis, R J, Cybulski, C, Wokołorczyk, D, Lubiński, J, Neal, D E, Donovan, J L, Hamdy, F C, Martin, R M, Nordestgaard, B G, Nielsen, S F, Weischer, M, Bojesen, S E, Røder, M A, Iversen, P, Batra, J, Chambers, S, Moya, L, Horvath, L, Clements, J A, Tilley, W, Risbridger, G P, Gronberg, H, Aly, M, Szulkin, R, Eklund, M, Nordström, T, Pashayan, N, Dunning, A M, Ghoussaini, M, Travis, R C, Key, T J, Riboli, E, Park, J Y, Sellers, T A, Lin, H-Y, Albanes, D, Weinstein, S J, Mucci, L A, Giovannucci, E, Lindstrom, S, Kraft, P, Hunter, D J, Penney, K L, Turman, C, Tangen, C M, Goodman, P J, Thompson, I M, Hamilton, R J, Fleshner, N E, Finelli, A, Parent, M-É, Stanford, J L, Ostrander, E A, Geybels, M S, Koutros, S, Freeman, L E B, Stampfer, M, Wolk, A, Håkansson, N, Andriole, G L, Hoover, R N, Machiela, M J, Sørensen, K D, Borre, M, Blot, W J, Zheng, W, Yeboah, E D, Mensah, J E, Lu, Y-J, Zhang, H-W, Feng, N, Mao, X, Wu, Y, Zhao, S-C, Sun, Z, Thibodeau, S N, McDonnell, S K, Schaid, D J, West, C M L, Burnet, N, Barnett, G, Maier, C, Schnoeller, T, Luedeke, M, Kibel, A S, Drake, B F, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Koudou, Y A, John, E M, Grindedal, E M, Maehle, L, Khaw, K-T, Ingles, S A, Stern, M C, Vega, A, Gómez-Caamaño, A, Fachal, L, Rosenstein, B S, Kerns, S L, Ostrer, H, Teixeira, M R, Paulo, P, Brandão, A, Watya, S, Lubwama, A, Bensen, J T, Fontham, E T H, Mohler, J, Taylor, J A, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Cannon-Albright, L, Teerlink, C C, Huff, C D, Strom, S S, Multigner, L, Blanchet, P, Brureau, L, Kaneva, R, Slavov, C, Mitev, V, Leach, R J, Weaver, B, Brenner, H, Cuk, K, Holleczek, B, Saum, K-U, Klein, E A, Hsing, A W, Kittles, R A, Murphy, A B, Logothetis, C J, Kim, J, Neuhausen, S L, Steele, L, Ding, Y C, Isaacs, W B, Nemesure, B, Hennis, A J M, Carpten, J, Pandha, H, Michael, A, De Ruyck, K, De Meerleer, G, Ost, P, Xu, J, Razack, A, Lim, J, Teo, S-H, Newcomb, L F, Lin, D W, Fowke, J H, Neslund-Dudas, C, Rybicki, B A, Gamulin, M, Lessel, D, Kulis, T, Usmani, N, Singhal, S, Parliament, M, Claessens, F, Joniau, S, Van den Broeck, T, Gago-Dominguez, M, Castelao, J E, Martinez, M E, Larkin, S, Townsend, P A, Aukim-Hastie, C, Bush, W S, Aldrich, M C, Crawford, D C, Srivastava, S, Cullen, J C, Petrovics, G, Casey, G, Roobol, M J, Jenster, G, van Schaik, R H N, Hu, J J, Sanderson, M, Varma, R, McKean-Cowdin, R, Torres, M, Mancuso, N, Berndt, S I, Van Den Eeden, S K, Easton, D F, Chanock, S J, Cook, M B, Wiklund, F, Nakagawa, H, Witte, J S, Eeles, R A, Kote-Jarai, Z & Haiman, C A 2021, ' Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction ', Nature Genetics, vol. 53, no. 1, pp. 65-75 . https://doi.org/10.1038/s41588-020-00748-0, Nature Genetics, Nature Genetics, Nature Publishing Group, 2021, 53 (1), pp.65-75. ⟨10.1038/s41588-020-00748-0⟩, Nature Genetics, 2021, 53 (1), pp.65-75. ⟨10.1038/s41588-020-00748-0⟩, Conti, D V, Donovan, J L, Martin, R M, Haiman, C A & al., E 2021, ' Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction ', Nature Genetics, vol. 53, no. 1, pp. 65–75 . https://doi.org/10.1038/s41588-020-00748-0, Nature Genetics, 53(1), 65-75. Nature Publishing Group, Conti, D V, Darst, B F, Moss, L C, Saunders, E J, Sheng, X, Chou, A, Schumacher, F R, Olama, A A A, Benlloch, S, Dadaev, T, Brook, M N, Sahimi, A, Hoffmann, T J, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Muir, K, Lophatananon, A, Wan, P, Le Marchand, L, Wilkens, L R, Stevens, V L, Gapstur, S M, Carter, B D, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Giles, G G, Southey, M C, MacInnis, R J, Cybulski, C, Wokołorczyk, D, Lubiński, J, Neal, D E, Donovan, J L, Hamdy, F C, Martin, R M, Nordestgaard, B G, Nielsen, S F, Weischer, M, Bojesen, S E, Røder, M A, Iversen, P, Batra, J, Chambers, S, Moya, L, Horvath, L, Clements, J A, Tilley, W, Risbridger, G P, Gronberg, H, Aly, M, Szulkin, R, Eklund, M, Nordström, T, Pashayan, N, Dunning, A M, Ghoussaini, M, Travis, R C, Key, T J, Riboli, E, Park, J Y, Sellers, T A, Lin, H Y, Albanes, D, Weinstein, S J, Mucci, L A, Giovannucci, E, Lindstrom, S, Kraft, P, Hunter, D J, Penney, K L, Turman, C, Tangen, C M, Goodman, P J, Thompson, I M, Hamilton, R J, Fleshner, N E, Finelli, A, Parent, M É, Stanford, J L, Ostrander, E A, Geybels, M S, Koutros, S, Freeman, L E B, Stampfer, M, Wolk, A, Håkansson, N, Andriole, G L, Hoover, R N, Machiela, M J, Sørensen, K D, Borre, M, Blot, W J, Zheng, W, Yeboah, E D, Mensah, J E, Lu, Y J, Zhang, H W, Feng, N, Mao, X, Wu, Y, Zhao, S C, Sun, Z, Thibodeau, S N, McDonnell, S K, Schaid, D J, West, C M L, Burnet, N, Barnett, G, Maier, C, Schnoeller, T, Luedeke, M, Kibel, A S, Drake, B F, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Koudou, Y A, John, E M, Grindedal, E M, Maehle, L, Khaw, K T, Ingles, S A, Stern, M C, Vega, A, Gómez-Caamaño, A, Fachal, L, Rosenstein, B S, Kerns, S L, Ostrer, H, Teixeira, M R, Paulo, P, Brandão, A, Watya, S, Lubwama, A, Bensen, J T, Fontham, E T H, Mohler, J, Taylor, J A, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Cannon-Albright, L, Teerlink, C C, Huff, C D, Strom, S S, Multigner, L, Blanchet, P, Brureau, L, Kaneva, R, Slavov, C, Mitev, V, Leach, R J, Weaver, B, Brenner, H, Cuk, K, Holleczek, B, Saum, K U, Klein, E A, Hsing, A W, Kittles, R A, Murphy, A B, Logothetis, C J, Kim, J, Neuhausen, S L, Steele, L, Ding, Y C, Isaacs, W B, Nemesure, B, Hennis, A J M, Carpten, J, Pandha, H, Michael, A, De Ruyck, K, De Meerleer, G, Ost, P, Xu, J, Razack, A, Lim, J, Teo, S H, Newcomb, L F, Lin, D W, Fowke, J H, Neslund-Dudas, C, Rybicki, B A, Gamulin, M, Lessel, D, Kulis, T, Usmani, N, Singhal, S, Parliament, M, Claessens, F, Joniau, S, Van den Broeck, T, Gago-Dominguez, M, Castelao, J E, Martinez, M E, Larkin, S, Townsend, P A, Aukim-Hastie, C, Bush, W S, Aldrich, M C, Crawford, D C, Srivastava, S, Cullen, J C, Petrovics, G, Casey, G, Roobol, M J, Jenster, G, van Schaik, R H N, Hu, J J, Sanderson, M, Varma, R, McKean-Cowdin, R, Torres, M, Mancuso, N, Berndt, S I, Van Den Eeden, S K, Easton, D F, Chanock, S J, Cook, M B, Wiklund, F, Nakagawa, H, Witte, J S, Eeles, R A, Kote-Jarai, Z & Haiman, C A 2021, ' Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction ', Nature Genetics, vol. 53, no. 1, pp. 65-75 . https://doi.org/10.1038/s41588-020-00748-0, Nature genetics
- Publication Year :
- 2021
- Publisher :
- Nature Research, 2021.
-
Abstract
- International audience; Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.
- Subjects :
- Male
8Q24
Genome-wide association study
Continental Population Groups/genetics
VARIANTS
Prostate cancer
0302 clinical medicine
Risk Factors
Epidemiology
IMPUTATION
Odds Ratio
Prostatic Neoplasms/diagnosis
0303 health sciences
education.field_of_study
Continental Population Groups
Manchester Cancer Research Centre
Middle Aged
Càncer--Aspectes genètics
3. Good health
ODDS RATIOS
06 Biological Sciences, 11 Medical and Health Sciences
medicine.medical_specialty
Population
Biology
prostate cancer
meta-analysis
SEQUENCE
Article
03 medical and health sciences
Breast cancer
SDG 3 - Good Health and Well-being
Genetics
medicine
BREAST-CANCER
Humans
Genetic Predisposition to Disease
Neoplasm Invasiveness
education
030304 developmental biology
Genetic association
[SDV.GEN]Life Sciences [q-bio]/Genetics
MUTATIONS
ResearchInstitutes_Networks_Beacons/mcrc
Racial Groups
Prostatic Neoplasms
Molecular Sequence Annotation
Odds ratio
medicine.disease
BRCA2
Pròstata--Càncer
Genetic Loci
030217 neurology & neurosurgery
Imputation (genetics)
Genètica
Demography
Developmental Biology
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 10614036 and 15461718
- Database :
- OpenAIRE
- Journal :
- Conti, D V, Darst, B F, Moss, L C, Saunders, E J, Sheng, X, Chou, A, Schumacher, F R, Olama, A A A, Benlloch, S, Dadaev, T, Brook, M N, Sahimi, A, Hoffmann, T J, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Muir, K, Lophatananon, A, Wan, P, Le Marchand, L, Wilkens, L R, Stevens, V L, Gapstur, S M, Carter, B D, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Giles, G G, Southey, M C, MacInnis, R J, Cybulski, C, Wokołorczyk, D, Lubiński, J, Neal, D E, Donovan, J L, Hamdy, F C, Martin, R M, Nordestgaard, B G, Nielsen, S F, Weischer, M, Bojesen, S E, Røder, M A, Iversen, P, Batra, J, Chambers, S, Moya, L, Horvath, L, Clements, J A, Tilley, W, Risbridger, G P, Gronberg, H, Aly, M, Szulkin, R, Eklund, M, Nordström, T, Pashayan, N, Dunning, A M, Ghoussaini, M, Travis, R C, Key, T J, Riboli, E, Park, J Y, Sellers, T A, Lin, H-Y, Albanes, D, Weinstein, S J, Mucci, L A, Giovannucci, E, Lindstrom, S, Kraft, P, Hunter, D J, Penney, K L, Turman, C, Tangen, C M, Goodman, P J, Thompson, I M, Hamilton, R J, Fleshner, N E, Finelli, A, Parent, M-É, Stanford, J L, Ostrander, E A, Geybels, M S, Koutros, S, Freeman, L E B, Stampfer, M, Wolk, A, Håkansson, N, Andriole, G L, Hoover, R N, Machiela, M J, Sørensen, K D, Borre, M, Blot, W J, Zheng, W, Yeboah, E D, Mensah, J E, Lu, Y-J, Zhang, H-W, Feng, N, Mao, X, Wu, Y, Zhao, S-C, Sun, Z, Thibodeau, S N, McDonnell, S K, Schaid, D J, West, C M L, Burnet, N, Barnett, G, Maier, C, Schnoeller, T, Luedeke, M, Kibel, A S, Drake, B F, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Koudou, Y A, John, E M, Grindedal, E M, Maehle, L, Khaw, K-T, Ingles, S A, Stern, M C, Vega, A, Gómez-Caamaño, A, Fachal, L, Rosenstein, B S, Kerns, S L, Ostrer, H, Teixeira, M R, Paulo, P, Brandão, A, Watya, S, Lubwama, A, Bensen, J T, Fontham, E T H, Mohler, J, Taylor, J A, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Cannon-Albright, L, Teerlink, C C, Huff, C D, Strom, S S, Multigner, L, Blanchet, P, Brureau, L, Kaneva, R, Slavov, C, Mitev, V, Leach, R J, Weaver, B, Brenner, H, Cuk, K, Holleczek, B, Saum, K-U, Klein, E A, Hsing, A W, Kittles, R A, Murphy, A B, Logothetis, C J, Kim, J, Neuhausen, S L, Steele, L, Ding, Y C, Isaacs, W B, Nemesure, B, Hennis, A J M, Carpten, J, Pandha, H, Michael, A, De Ruyck, K, De Meerleer, G, Ost, P, Xu, J, Razack, A, Lim, J, Teo, S-H, Newcomb, L F, Lin, D W, Fowke, J H, Neslund-Dudas, C, Rybicki, B A, Gamulin, M, Lessel, D, Kulis, T, Usmani, N, Singhal, S, Parliament, M, Claessens, F, Joniau, S, Van den Broeck, T, Gago-Dominguez, M, Castelao, J E, Martinez, M E, Larkin, S, Townsend, P A, Aukim-Hastie, C, Bush, W S, Aldrich, M C, Crawford, D C, Srivastava, S, Cullen, J C, Petrovics, G, Casey, G, Roobol, M J, Jenster, G, van Schaik, R H N, Hu, J J, Sanderson, M, Varma, R, McKean-Cowdin, R, Torres, M, Mancuso, N, Berndt, S I, Van Den Eeden, S K, Easton, D F, Chanock, S J, Cook, M B, Wiklund, F, Nakagawa, H, Witte, J S, Eeles, R A, Kote-Jarai, Z & Haiman, C A 2021, ' Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction ', Nature Genetics, vol. 53, no. 1, pp. 65-75 . https://doi.org/10.1038/s41588-020-00748-0, Nature Genetics, Nature Genetics, Nature Publishing Group, 2021, 53 (1), pp.65-75. ⟨10.1038/s41588-020-00748-0⟩, Nature Genetics, 2021, 53 (1), pp.65-75. ⟨10.1038/s41588-020-00748-0⟩, Conti, D V, Donovan, J L, Martin, R M, Haiman, C A & al., E 2021, ' Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction ', Nature Genetics, vol. 53, no. 1, pp. 65–75 . https://doi.org/10.1038/s41588-020-00748-0, Nature Genetics, 53(1), 65-75. Nature Publishing Group, Conti, D V, Darst, B F, Moss, L C, Saunders, E J, Sheng, X, Chou, A, Schumacher, F R, Olama, A A A, Benlloch, S, Dadaev, T, Brook, M N, Sahimi, A, Hoffmann, T J, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Muir, K, Lophatananon, A, Wan, P, Le Marchand, L, Wilkens, L R, Stevens, V L, Gapstur, S M, Carter, B D, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Giles, G G, Southey, M C, MacInnis, R J, Cybulski, C, Wokołorczyk, D, Lubiński, J, Neal, D E, Donovan, J L, Hamdy, F C, Martin, R M, Nordestgaard, B G, Nielsen, S F, Weischer, M, Bojesen, S E, Røder, M A, Iversen, P, Batra, J, Chambers, S, Moya, L, Horvath, L, Clements, J A, Tilley, W, Risbridger, G P, Gronberg, H, Aly, M, Szulkin, R, Eklund, M, Nordström, T, Pashayan, N, Dunning, A M, Ghoussaini, M, Travis, R C, Key, T J, Riboli, E, Park, J Y, Sellers, T A, Lin, H Y, Albanes, D, Weinstein, S J, Mucci, L A, Giovannucci, E, Lindstrom, S, Kraft, P, Hunter, D J, Penney, K L, Turman, C, Tangen, C M, Goodman, P J, Thompson, I M, Hamilton, R J, Fleshner, N E, Finelli, A, Parent, M É, Stanford, J L, Ostrander, E A, Geybels, M S, Koutros, S, Freeman, L E B, Stampfer, M, Wolk, A, Håkansson, N, Andriole, G L, Hoover, R N, Machiela, M J, Sørensen, K D, Borre, M, Blot, W J, Zheng, W, Yeboah, E D, Mensah, J E, Lu, Y J, Zhang, H W, Feng, N, Mao, X, Wu, Y, Zhao, S C, Sun, Z, Thibodeau, S N, McDonnell, S K, Schaid, D J, West, C M L, Burnet, N, Barnett, G, Maier, C, Schnoeller, T, Luedeke, M, Kibel, A S, Drake, B F, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Koudou, Y A, John, E M, Grindedal, E M, Maehle, L, Khaw, K T, Ingles, S A, Stern, M C, Vega, A, Gómez-Caamaño, A, Fachal, L, Rosenstein, B S, Kerns, S L, Ostrer, H, Teixeira, M R, Paulo, P, Brandão, A, Watya, S, Lubwama, A, Bensen, J T, Fontham, E T H, Mohler, J, Taylor, J A, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Cannon-Albright, L, Teerlink, C C, Huff, C D, Strom, S S, Multigner, L, Blanchet, P, Brureau, L, Kaneva, R, Slavov, C, Mitev, V, Leach, R J, Weaver, B, Brenner, H, Cuk, K, Holleczek, B, Saum, K U, Klein, E A, Hsing, A W, Kittles, R A, Murphy, A B, Logothetis, C J, Kim, J, Neuhausen, S L, Steele, L, Ding, Y C, Isaacs, W B, Nemesure, B, Hennis, A J M, Carpten, J, Pandha, H, Michael, A, De Ruyck, K, De Meerleer, G, Ost, P, Xu, J, Razack, A, Lim, J, Teo, S H, Newcomb, L F, Lin, D W, Fowke, J H, Neslund-Dudas, C, Rybicki, B A, Gamulin, M, Lessel, D, Kulis, T, Usmani, N, Singhal, S, Parliament, M, Claessens, F, Joniau, S, Van den Broeck, T, Gago-Dominguez, M, Castelao, J E, Martinez, M E, Larkin, S, Townsend, P A, Aukim-Hastie, C, Bush, W S, Aldrich, M C, Crawford, D C, Srivastava, S, Cullen, J C, Petrovics, G, Casey, G, Roobol, M J, Jenster, G, van Schaik, R H N, Hu, J J, Sanderson, M, Varma, R, McKean-Cowdin, R, Torres, M, Mancuso, N, Berndt, S I, Van Den Eeden, S K, Easton, D F, Chanock, S J, Cook, M B, Wiklund, F, Nakagawa, H, Witte, J S, Eeles, R A, Kote-Jarai, Z & Haiman, C A 2021, ' Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction ', Nature Genetics, vol. 53, no. 1, pp. 65-75 . https://doi.org/10.1038/s41588-020-00748-0, Nature genetics
- Accession number :
- edsair.doi.dedup.....1a27e581a69c75f35d954ecb341f4f49