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CDK4, CDK6/cyclin‐d1 complex inhibition and radiotherapy for cancer control: a role for autophagy
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 8391, p 8391 (2021), International Journal of Molecular Sciences
- Publication Year :
- 2021
-
Abstract
- The expanding clinical application of CDK4- and CDK6-inhibiting drugs in the managements of breast cancer has raised a great interest in testing these drugs in other neoplasms. The potential of combining these drugs with other therapeutic approaches seems to be an interesting work-ground to explore. Even though a potential integration of CDK4 and CDK6 inhibitors with radiotherapy (RT) has been hypothesized, this kind of approach has not been sufficiently pursued, neither in preclinical nor in clinical studies. Similarly, the most recent discoveries focusing on autophagy, as a possible target pathway able to enhance the antitumor efficacy of CDK4 and CDK6 inhibitors is promising but needs more investigations. The aim of this review is to discuss the recent literature on the field in order to infer a rational combination strategy including cyclin-D1/CDK4-CDK6 inhibitors, RT, and/or other anticancer agents targeting G1-S phase cell cycle transition.
- Subjects :
- Phase cell
QH301-705.5
medicine.medical_treatment
Antineoplastic Agents
Review
Catalysis
Inorganic Chemistry
Antineoplastic Agent
Cyclin D1
Breast cancer
Cancer control
Neoplasms
Combination strategy
medicine
Autophagy
Animals
Humans
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
Protein Kinase Inhibitors
QD1-999
Spectroscopy
biology
Radiotherapy
business.industry
Animal
Cyclin inhibitor
Organic Chemistry
Cell Cycle
Cyclin-Dependent Kinase 4
General Medicine
Chemoradiotherapy
Cyclin-Dependent Kinase 6
medicine.disease
Cyclin inhibitors
Computer Science Applications
Radiation therapy
Chemistry
biology.protein
Cancer research
Neoplasm
Cyclin-dependent kinase 6
business
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, Vol 22, Iss 8391, p 8391 (2021), International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....1a2e017b2de54f7585d5e615d461dfb8