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Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine
- Source :
- Psychopharmacology. 234(7)
- Publication Year :
- 2016
-
Abstract
- Here, we present the data indicating that chronic treatment with fluoxetine regulates Cav-1/PTEN/PI3K/AKT/GSK-3β signalling pathway and glycogen content in primary cultures of astrocytes with bi-phasic concentration dependence. At lower concentrations, fluoxetine downregulates gene expression of Cav-1, decreases membrane content of PTEN, increases activity of PI3K/AKT, and elevates GSK-3β phosphorylation thus suppressing its activity. At higher concentrations, fluoxetine acts in an inverse fashion. As expected, fluoxetine at lower concentrations increased while at higher concentrations decreased glycogen content in astrocytes. Our findings indicate that bi-phasic regulation of glycogen content via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine may be responsible for both therapeutic and side effects of the drug.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Class I Phosphatidylinositol 3-Kinases
Caveolin 1
Primary Cell Culture
03 medical and health sciences
chemistry.chemical_compound
Mice
Phosphatidylinositol 3-Kinases
0302 clinical medicine
Internal medicine
Fluoxetine
Gene expression
medicine
PTEN
Animals
Phosphorylation
RNA, Small Interfering
Protein kinase B
PI3K/AKT/mTOR pathway
Pharmacology
Glycogen Synthase Kinase 3 beta
Glycogen
biology
PTEN Phosphohydrolase
Hedgehog signaling pathway
030104 developmental biology
Endocrinology
chemistry
Astrocytes
Gene Knockdown Techniques
biology.protein
030217 neurology & neurosurgery
Selective Serotonin Reuptake Inhibitors
medicine.drug
Signal Transduction
Subjects
Details
- ISSN :
- 14322072
- Volume :
- 234
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....1a4c594a8db728a6fac9dba88d415847