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Soluble HLA-G in pregnancies complicated by autoimmune rheumatic diseases
- Source :
- Journal of Reproductive Immunology. 110:67-73
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Autoimmune rheumatic diseases in pregnancies are associated with increased adverse obstetric outcomes. We compared maternal soluble human leucocyte antigen-G (sHLA-G) blood levels in subjects with a rheumatic disease preexisting pregnancy and unaffected controls. Third-trimester blood maternal sHLA-G concentrations were significantly higher in subjects with rheumatic diseases than in controls (mean 93.1ng/ml [SD 42.1] vs 58.1ng/ml [SD 96.3], p=0.003). Cord blood sHLA-G concentrations were significantly higher in rheumatic disease than in those born to control mothers (median 41.2ng/ml [IQR: 3.3-44.0] vs 17.9ng/ml [IQR: 17.2-88.1], p=0.007). A strict positive correlation (r=0.88, p
- Subjects :
- Adult
medicine.medical_specialty
Immunology
Human leukocyte antigen
Gastroenterology
Autoimmune Diseases
Immune tolerance
Immune system
Pregnancy
Polymorphism (computer science)
Rheumatic Diseases
Internal medicine
Humans
Immunology and Allergy
Medicine
HLA-G Antigens
Fetus
Polymorphism, Genetic
business.industry
Homozygote
Autoantibody
Obstetrics and Gynecology
medicine.disease
Endocrinology
Reproductive Medicine
Antibodies, Antinuclear
Cord blood
Female
business
Subjects
Details
- ISSN :
- 01650378
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Journal of Reproductive Immunology
- Accession number :
- edsair.doi.dedup.....1a7eef63fe741a243944e282df55c541