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Influence of Ionic Additives on Triclinic Calcium Pyrophosphate Dihydrate Precipitation
- Source :
- Crystal Growth & Design, Crystal Growth & Design, American Chemical Society, 2017, 17 (1), pp.37-50. ⟨10.1021/acs.cgd.6b01128⟩, Crystal Growth & Design, 2017, 17 (1), pp.37-50. ⟨10.1021/acs.cgd.6b01128⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- International audience; Triclinic Calcium pyrophosphate dihydrate (t-CPPD) crystals are one of the two polymorphs of micro crystals that have been found in the joints of patients suffering from pseudogout. Howeyer, there is currently no treatment for inhibiting the formation of these crystals, which present a high inflammatory potential. In this context we studied in vitro the precipitation of t-CPPD in a stirred reactor under pH- and temperature-controlled conditions and determined the effect of selected biologically relevant ionic additives Mg2+, Cu2+, Fe3+, Zn2+, S2O32-) on its formation. The results showed that 1 mM Fe3+, Zn2+, Or Cu2+ induced the most significant Changes by partly inhibiting, the crystallization of t-CPPD and favoring the formation of an amorphous-CPP phase (98 Wt %) in the presence of Fe3+ or a monoclinic-CPPD phase (78 or 71 wt %, respectively) in the presence of Zn2+ or CO2. Correlations between P-31 solid-state NMR, XRD, and elemental analyses showed that the additive cations are inserted into the monoclinic-CPPD and/or amorphous-CPP phases. This study, which combines structural, morphological, and elemental analyses, paves the way toward a deeper comprehension of the role of ionic additives in preventing the formation of CPPD crystalline phases, and is a key step in long-term development of an effective therapeutic treatment.
- Subjects :
- musculoskeletal diseases
inorganic chemicals
Calcium pyrophosphate
Matériaux
Ionic bonding
Context (language use)
02 engineering and technology
Precipitation
Triclinic crystal system
010402 general chemistry
01 natural sciences
law.invention
chemistry.chemical_compound
[CHIM.GENI]Chemical Sciences/Chemical engineering
law
Phase (matter)
General Materials Science
Crystallization
Solid state NMR
Precipitation (chemistry)
Chemistry
Ionic additives
General Chemistry
[CHIM.MATE]Chemical Sciences/Material chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
0104 chemical sciences
Crystallography
Pseudogout
0210 nano-technology
Nuclear chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 15287483 and 15287505
- Database :
- OpenAIRE
- Journal :
- Crystal Growth & Design, Crystal Growth & Design, American Chemical Society, 2017, 17 (1), pp.37-50. ⟨10.1021/acs.cgd.6b01128⟩, Crystal Growth & Design, 2017, 17 (1), pp.37-50. ⟨10.1021/acs.cgd.6b01128⟩
- Accession number :
- edsair.doi.dedup.....1a7fcf5d9b1ad2c954401eb5fab99cb0