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Correlates of Residual Limb Pain: From Residual Limb Length and Usage to Metabolites and Activity in Secondary Somatosensory Cortex
Correlates of Residual Limb Pain: From Residual Limb Length and Usage to Metabolites and Activity in Secondary Somatosensory Cortex
- Source :
- IEEE Transactions on Neural Systems and Rehabilitation Engineering. 27:96-104
- Publication Year :
- 2019
- Publisher :
- Institute of Electrical and Electronics Engineers (IEEE), 2019.
-
Abstract
- Most recent studies attribute residual limb pain to peripheral pathological changes of the stump. However, in this paper, we focus on its associations with the residual limb length, usage, as well as the metabolic and functional alterations of the brain. The secondary somatosensory cortex (S2), one important area involved in pain intensity discrimination, was selected as the region of interest. Twenty-two upper-limb amputees were recruited and divided into two groups, i.e., amputees with residual limb pain (9/22) and without residual limb pain (13/22). The residual limb length, usage, as well as the metabolite concentration, resting-state activity and BOLD responses to the tactile stimulation in the contralateral S2, were compared between the two groups and correlated with the pain intensity. The amputees with residual limb pain showed significantly shorter length and less usage of the residual limb than the amputees without residual limb pain, and the pain intensity was significantly negatively correlated with the residual limb length and usage. In addition, the pain intensity was significantly correlated with the tNAA/tCr ratio, resting-state fALFF in the slow-4 band, and BOLD response to the tactile stimulation in the contralateral S2, although there were no significant group differences. Regression analysis suggested that residual limb pain is associated with shorter residual limb length and less residual limb usage.
- Subjects :
- Adult
Male
medicine.medical_specialty
Elbow
Biomedical Engineering
Pain
Functional Laterality
030218 nuclear medicine & medical imaging
Upper Extremity
03 medical and health sciences
Oxygen Consumption
0302 clinical medicine
Physical medicine and rehabilitation
Amputees
Physical Stimulation
Internal Medicine
medicine
Humans
Aged
Pain Measurement
Sensory stimulation therapy
medicine.diagnostic_test
Secondary somatosensory cortex
business.industry
General Neuroscience
Amputation Stumps
Rehabilitation
Magnetic resonance imaging
Somatosensory Cortex
Middle Aged
Magnetic Resonance Imaging
Peripheral
Intensity (physics)
body regions
medicine.anatomical_structure
Phantom Limb
Creatinine
Female
Functional magnetic resonance imaging
business
030217 neurology & neurosurgery
Residual limb
Subjects
Details
- ISSN :
- 15580210 and 15344320
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Accession number :
- edsair.doi.dedup.....1a7fd808e4faf210ecf54d232a659b12
- Full Text :
- https://doi.org/10.1109/tnsre.2018.2885146