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Critical roles of TRPV2 channels, histamine H1 and adenosine A1 receptors in the initiation of acupoint signals for acupuncture analgesia
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Acupuncture is one of the most promising modalities in complimentary medicine. However, the underlying mechanisms are not well understood yet. We found that in TRPV2 knockout male mice, acupuncture-induced analgesia was suppressed with a decreased activation of mast cells in the acupoints stimulated. The mast cell stabilizer sodium cromolyn could suppress the release of adenosine in the acupoints on male rats. A direct injection of adenosine A1 receptor agonist or histamine H1 receptor agonist increased β-endorphin in the cerebral-spinal fluid in the acute adjuvant arthritis male rats and thus replicated the analgesic effect of acupuncture. These observations suggest that the mast cell is the central structure of acupoints and is activated by acupuncture through TRPV2 channels. The mast cell transduces the mechanical stimuli to acupuncture signal by activating either H1 or A1 receptors, therefore triggering the acupuncture effect in the subject. These findings might open new frontiers for acupuncture research.
- Subjects :
- 0301 basic medicine
Agonist
Male
Adenosine
medicine.drug_class
Acupuncture Therapy
TRPV Cation Channels
lcsh:Medicine
Pharmacology
Article
Histamine Agonists
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
Adenosine A1 receptor
Mice
0302 clinical medicine
Cromolyn Sodium
Acupuncture
Medicine
Animals
Mast cell stabilizer
Acupuncture Analgesia
Mast Cells
Receptor
lcsh:Science
Mice, Knockout
Multidisciplinary
business.industry
Receptor, Adenosine A1
beta-Endorphin
lcsh:R
Mast cell
Arthritis, Experimental
Rats
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
chemistry
lcsh:Q
Calcium Channels
business
Acupuncture Points
030217 neurology & neurosurgery
Histamine
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....1a9e54579df44f145fb2ddd06823ec46