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Donor organ cultured corneal tissue selection before penetrating keratoplasty
- Publication Year :
- 1998
-
Abstract
- AIMS—Donor organ cultured corneal tissue selection before penetrating keratoplasty is carried out by taking into account different variables. The objective was to identify preoperative variables which are significantly and independently associated with transplant outcome and should effectively be taken into account before transplantation. METHODS—231 consecutive penetrating keratoplasties were prospectively studied using organ cultured tissue. Morphometric analysis of the donor corneal endothelium was performed before transplantation. Graft survival and endothelial cell density, during the second year following transplantation, were studied both at a univariate and multivariate level. RESULTS—Recipient age, recipient rejection status, and preoperative diagnosis significantly influenced graft survival. Graft survival was higher when using corneal tissue from donors older than 80 years. Postoperative endothelial density decreased with preservation time and coefficient of variation after preservation. It increased with endothelial cell density after preservation and deswelling time, and correlated with preoperative diagnosis. CONCLUSION—Organ cultured corneas with endothelial cell density after preservation
- Subjects :
- Adult
medicine.medical_specialty
Corneal endothelium
Adolescent
Transplants
Cell Count
Cellular and Molecular Neuroscience
Tissue culture
Corneal edema
Cornea
Culture Techniques
Medicine
Humans
Prospective Studies
Child
Aged
Aged, 80 and over
business.industry
Endothelium, Corneal
Graft Survival
Middle Aged
Original articles - Clinical science
Sensory Systems
Surgery
Transplantation
Endothelial cell density
Ophthalmology
medicine.anatomical_structure
surgical procedures, operative
Penetrating Keratoplasties
Multivariate Analysis
business
Complication
Keratoplasty, Penetrating
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1aa03a780fbdf507375a4f0de7195985