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An ALP-activatable and mitochondria-targeted probe for prostate cancer-specific bimodal imaging and aggregation-enhanced photothermal therapy
- Source :
- Nanoscale. 11:6307-6314
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- Tumor-derived alkaline phosphatase (ALP) is over-expressed in metastatic prostate cancer. The development of selective probes for ALP detection is therefore critical for early diagnosis and therapy of metastatic prostate cancer. Herein, we develop a mitochondria-targeted near-infrared activatable fluorescent/photoacoustic (NIR FL/PA) probe for the selective detection of prostate cancer-derived ALP and aggregation-enhanced photothermal therapy. Upon dephosphorylation, the probes are activated and they provide a red-shifted strong absorption and emission in the NIR window and thus enable NIR FL and PA imaging of ALP activity in tumor tissues. Particularly, the activated probes self-assemble in situ into a supramolecular network structure which induces cell apoptosis and significantly enhances the photothermal therapy efficacy.
- Subjects :
- Male
Cell Survival
Infrared Rays
Mice, Nude
02 engineering and technology
010402 general chemistry
01 natural sciences
Photoacoustic Techniques
Dephosphorylation
Mice
Prostate cancer
Prostate
Cell Line, Tumor
medicine
Animals
Humans
Tissue Distribution
General Materials Science
Enzyme Inhibitors
Fluorescent Dyes
Mice, Inbred BALB C
Spectroscopy, Near-Infrared
Chemistry
Prostatic Neoplasms
Phototherapy
Photothermal therapy
Alkaline Phosphatase
021001 nanoscience & nanotechnology
medicine.disease
Fluorescence
Mitochondria
0104 chemical sciences
medicine.anatomical_structure
Microscopy, Fluorescence
Cell culture
Apoptosis
Cancer research
Alkaline phosphatase
0210 nano-technology
Subjects
Details
- ISSN :
- 20403372 and 20403364
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nanoscale
- Accession number :
- edsair.doi.dedup.....1aa8fb564c424d52b86d1d92c132e6da