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Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Meningitis, England and Wales, July 1, 2000–June 30, 2016
- Source :
- Emerging Infectious Diseases, Vol 25, Iss 9, Pp 1708-1718 (2019), Emerging Infectious Diseases
- Publication Year :
- 2019
- Publisher :
- Centers for Disease Control and Prevention (CDC), 2019.
-
Abstract
- We describe the effects of the 7-valent (PCV7) and 13-valent (PCV13) pneumococcal conjugate vaccines on pneumococcal meningitis in England and Wales during July 1, 2000–June 30, 2016. Overall, 84,473 laboratory-confirmed invasive pneumococcal disease cases, including 4,160 (4.9%) cases with meningitis, occurred. PCV7 implementation in 2006 did not lower overall pneumococcal meningitis incidence because of replacement with non–PCV7-type meningitis incidence. Replacement with PCV13 in 2010, however, led to a 48% reduction in pneumococcal meningitis incidence by 2015–16. The overall case-fatality rate was 17.5%: 10.7% among patients 65 years of age. Serotype 8 was associated with increased odds of death (adjusted odds ratio 2.9, 95% CI 1.8–4.7). In England and Wales, an effect on pneumococcal meningitis was observed only after PCV13 implementation. Further studies are needed to assess pneumococcal meningitis caused by the replacing serotypes.
- Subjects :
- Male
Serotype
Pediatrics
Heptavalent Pneumococcal Conjugate Vaccine
Epidemiology
lcsh:Medicine
PCV13
medicine.disease_cause
Pneumococcal Vaccines
0302 clinical medicine
conjugate vaccines
Case fatality rate
serotype
030212 general & internal medicine
bacteria
Child
case fatality rate
Meningitis, Pneumococcal
Incidence
Incidence (epidemiology)
meningitis
PCV7
Middle Aged
Streptococcus pneumoniae
Infectious Diseases
England
Child, Preschool
Female
Meningitis
Adult
Microbiology (medical)
medicine.medical_specialty
Pneumococcal disease
Adolescent
030231 tropical medicine
serotype 8
immunization
case-fatality rate
invasive pneumococcal disease
Mass Vaccination
lcsh:Infectious and parasitic diseases
Young Adult
03 medical and health sciences
medicine
Humans
lcsh:RC109-216
Aged
pneumococcal meningitis
Wales
Vaccines, Conjugate
business.industry
Research
lcsh:R
Infant, Newborn
Infant
Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Meningitis, England and Wales, July 1, 2000–June 30, 2016
Odds ratio
medicine.disease
business
Subjects
Details
- Language :
- English
- ISSN :
- 10806040
- Database :
- OpenAIRE
- Journal :
- Emerging Infectious Diseases, Vol 25, Iss 9, Pp 1708-1718 (2019), Emerging Infectious Diseases
- Accession number :
- edsair.doi.dedup.....1adf10efd3d0387dde5e9e408e6977ba