Back to Search
Start Over
Gut microbiota signature of pathogen-dependent dysbiosis in viral gastroenteritis
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Acute gastroenteritis associated with diarrhea is considered a serious disease in Africa and South Asia. In this study, we examined the trends in the causative pathogens of diarrhea and the corresponding gut microbiota in Ghana using microbiome analysis performed on diarrheic stools via 16S rRNA sequencing. In total, 80 patients with diarrhea and 34 healthy adults as controls, from 2017 to 2018, were enrolled in the study. Among the patients with diarrhea, 39 were norovirus-positive and 18 were rotavirus-positive. The analysis of species richness (Chao1) was lower in patients with diarrhea than that in controls. Beta-diversity analysis revealed significant differences between the two groups. Several diarrhea-related pathogens (e.g., Escherichia-Shigella, Klebsiella and Campylobacter) were detected in patients with diarrhea. Furthermore, co-infection with these pathogens and enteroviruses (e.g., norovirus and rotavirus) was observed in several cases. Levels of both Erysipelotrichaceae and Staphylococcaceae family markedly differed between norovirus-positive and -negative diarrheic stools, and the 10 predicted metabolic pathways, including the carbohydrate metabolism pathway, showed significant differences between rotavirus-positive patients with diarrhea and controls. This comparative study of diarrheal pathogens in Ghana revealed specific trends in the gut microbiota signature associated with diarrhea and that pathogen-dependent dysbiosis occurred in viral gastroenteritis.
- Subjects :
- Adult
Diarrhea
Male
Rotavirus
0301 basic medicine
Adolescent
Epidemiology
Science
030106 microbiology
Gut flora
medicine.disease_cause
Ghana
Article
Microbiology
Feces
03 medical and health sciences
fluids and secretions
medicine
Humans
Microbiome
Child
Staphylococcaceae
Phylogeny
Multidisciplinary
Bacteria
biology
Campylobacter
Biodiversity
biology.organism_classification
medicine.disease
Gastroenteritis
Gastrointestinal Microbiome
030104 developmental biology
Case-Control Studies
Child, Preschool
Norovirus
Dysbiosis
Infectious diseases
Medicine
Female
medicine.symptom
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....1aeddbe1e751ec799ac258c055204909
- Full Text :
- https://doi.org/10.1038/s41598-021-93345-y