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Performances of creatinine-based glomerular filtration rate estimating equations in simultaneous pancreas-kidney transplant recipients: a single center cohort study
- Source :
- Transplant International: Official Journal of the European Society for Organ Transplantation, Transplant International: Official Journal of the European Society for Organ Transplantation, 2018, ⟨10.1111/tri.13333⟩, Transplant International, Transplant International, 2018, ⟨10.1111/tri.13333⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; Estimating glomerular filtration rate (GFR) is important for clinical management and research studies in simultaneous pancreas-kidney transplantation (SPK) recipients. No study has specifically investigated the reliability of recent creatinine-based GFR estimating equations in this singular population. We assessed the performances of CKD-EPI, MDRD, Schwartz-2009, Schwartz-Lyon, Lund-Malmo and Full Age Spectrum equations for estimating GFR after SPK. 126 patients were included. GFR was measured by a reference method (mGFR) one year after SPK and estimated with the different equations from a standardized measure of serum creatinine. Relative bias, precisions, 10% and 30% accuracies (P30) were used to determine equations reliability. Ages ranged from 29 to 58. Mean mGFR was 56.3 \textpm 13.3 [23.6-92.5] ml/min/1.73 m2 . In the whole population, P30 of the CKD-EPI and MDRD equations were 42% (38.0; 46.0) and 65% (61.5; 69) respectively. As compared to the other equations, the Schwartz-Lyon equation was significantly more accurate (P30 = 86.0% [83.5-88.0], P \textless 0.01) and less biased (1.13 [1.06-1.19], P \textless 0.01). Conclusions were similar whatever the age class (\textless40 or >=40) and mGFR level (\textless60 or >=60 ml/min/1.73 m2 ). This study suggests that the CKD-EPI and MDRD equations have poor performances in SPK recipients and that the Schwartz-Lyon equation is a reliable alternative.
- Subjects :
- Adult
Male
medicine.medical_specialty
Population
Urology
Renal function
030209 endocrinology & metabolism
Estimating equations
creatinine-based GFR estimating equations
Single Center
Kidney Function Tests
Kidney transplant
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Medicine
Humans
030212 general & internal medicine
Cystatin C
Renal Insufficiency, Chronic
education
simultaneous pancreas-kidney transplantation
Transplantation
Creatinine
education.field_of_study
glomerular filtration rate
business.industry
Reproducibility of Results
Middle Aged
Kidney Transplantation
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
chemistry
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Regression Analysis
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
Pancreas Transplantation
business
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 09340874 and 14322277
- Database :
- OpenAIRE
- Journal :
- Transplant International: Official Journal of the European Society for Organ Transplantation, Transplant International: Official Journal of the European Society for Organ Transplantation, 2018, ⟨10.1111/tri.13333⟩, Transplant International, Transplant International, 2018, ⟨10.1111/tri.13333⟩
- Accession number :
- edsair.doi.dedup.....1aff13a693cf8db73958f0a5ffe579ee