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Swelling behavior and controlled release of theophylline and sulfamethoxazole drugs in beta-lactoglobulin protein gels obtained by phase separation in water/ethanol mixture

Swelling behavior and controlled release of theophylline and sulfamethoxazole drugs in beta-lactoglobulin protein gels obtained by phase separation in water/ethanol mixture

Authors :
Thimma T. Reddy
Laurence Lavenant
Jacques Lefebvre
Denis Renard
Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA)
Institut National de la Recherche Agronomique (INRA)
Source :
Biomacromolecules, Biomacromolecules, American Chemical Society, 2006, 7 (1), pp.323-330. ⟨10.1021/bm050688d⟩
Publication Year :
2006
Publisher :
HAL CCSD, 2006.

Abstract

Physically cross-linked beta-lactoglobulin (BLG) protein gels containing theophylline and sulfamethoxazole low molecular weight drugs were prepared in 50% ethanol solution at pH 8 and two protein concentrations (6 and 7% (w/v)). Swelling behavior of cylindrical gels showed that, irrespective of the hydrated or dehydrated state of the gel, the rate of swelling was the highest in water. When the gels were exposed to water, they first showed a swelling phase in which their weight increased 3 and 30 times for hydrated and dehydrated gels, respectively, due to absorption of water, followed by a dissolution phase. The absorption of solvent was however considerably reduced when the gels were exposed to aqueous buffer solutions. The release behavior of both theophylline and sulfamethoxazole drugs from BLG gels was achieved in a time window ranging from 6 to 24 h. The drug release depended mainly on the solubility of the drugs and the physical state of the gel (hydrated or dry form). Analysis of drug release profiles using the model of Peppas showed that diffusion through hydrated gels was governed by a Fickian process whereas diffusion through dehydrated gels was governed partly by the swelling capacities of the gel but also by the structural rearrangements inside the network occurring during dehydration step. By a judicious selection of protein concentration, hydrated or dehydrated gel state, drug release may be modulated to be engineered suitable for pharmaceutical as well as cosmetics and food applications.

Details

Language :
English
ISSN :
15257797 and 15264602
Database :
OpenAIRE
Journal :
Biomacromolecules, Biomacromolecules, American Chemical Society, 2006, 7 (1), pp.323-330. ⟨10.1021/bm050688d⟩
Accession number :
edsair.doi.dedup.....1b1085a965eb71264b78deaa3d34d18d
Full Text :
https://doi.org/10.1021/bm050688d⟩