Remodeling human osteoarthritic articular cartilage rAAV-mediated via combined gene transfer and overexpression of TGF-beta and sox9

Authors :: Tao, K
Frisch, J
Rey Rico, A
Venkatesan, JK
Schmitt, G
Madry, H
Lin, JH
Cucchiarini Madry, M
Source :: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2016); 20161025-20161028; Berlin; DOCPO20-1183 /20161010/
Publication Year :: 2016
Publisher :: German Medical Science GMS Publishing House, 2016.
Abstract: Objectives: Direct administration of therapeutic candidate gene sequences using the safe and effective recombinant adeno-associated virus (rAAV) vectors is a promising strategy to stimulate the biologic activities of articular chondrocytes as an adapted tool to treat human osteoarthritic (OA) cartilage.[for full text, please go to the a.m. URL]<br />Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2016)

Subjects :: Cartilage
ddc: 610
viruses
Gene Therapy
610 Medical sciences
Medicine
Regenerative Medicine

Language :: English
Database :: OpenAIRE
Journal :: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2016); 20161025-20161028; Berlin; DOCPO20-1183 /20161010/
Accession number :: edsair.doi.dedup.....1b32e9ff912165b1d01755894ca0e928
Full Text :: https://doi.org/10.3205/16dkou659

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