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Dynamic Histone H3 Incorporation Fuels Metastatic Progression
- Source :
- Trends in Molecular Medicine, Trends in Molecular Medicine, Elsevier, 2019, 25 (11), pp.933-935. ⟨10.1016/j.molmed.2019.09.003⟩
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- International audience; Treating metastatic cancers is an ongoing challenge in oncology. A recent paper by Gomes and colleagues proposes histone H3 variant dynamics as major regulator of cell fate transition during metastasis and suggests histone chaperones as therapeutic targets for invasive carcinoma.; Le traitement des cancers métastatiques est un défi permanent en oncologie. Un article récent de Gomes et ses collègues propose la dynamique du variant de l'histone H3 comme régulateur majeur de la transition du destin cellulaire pendant la métastase et suggère les chaperons d'histones comme cibles thérapeutiques pour les carcinomes invasifs.
- Subjects :
- 0301 basic medicine
[SDV]Life Sciences [q-bio]
MESH: Chromatin / metabolism
Histone Chaperones / metabolism
Histones / metabolism
Humans
Neoplasm Metastasis / pathology
Neoplasms / pathology
Regulator
Biology
Cell fate determination
Metastasis
Histones
03 medical and health sciences
Histone H3
0302 clinical medicine
Neoplasms
histone H3 dynamics
medicine
Histone Chaperones
metastasis
Neoplasm Metastasis
Molecular Biology
CAF-1
Invasive carcinoma
Transition (genetics)
chromatin reprogramming
medicine.disease
Chromatin
3. Good health
030104 developmental biology
Cancer research
Molecular Medicine
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14714914
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Trends in Molecular Medicine
- Accession number :
- edsair.doi.dedup.....1b371ef5620dd6af5ff66e06c01b2dd6
- Full Text :
- https://doi.org/10.1016/j.molmed.2019.09.003