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Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates

Authors :
Anna St. Swierzko
Iwona Domzalska-Popadiuk
Misao Matsushita
Monika Borkowska-Klos
Jerzy Szczapa
Janusz Szemraj
Shirley Lynn Macdonald
Aleksandra Jopek
Maciej Cedzynski
Marc Turner
Agnieszka Szala
Anne P.M. Atkinson
David C. Kilpatrick
Source :
Molecular Immunology. 46:551-558
Publication Year :
2009
Publisher :
Elsevier BV, 2009.

Abstract

Ficolins and one collectin, mannan-binding lectin (MBL), are the only factors known to activate the lectin pathway (LP) of complement. There is considerable circumstantial evidence that MBL insufficiency can increase susceptibility to various infections and influence the course of several non-infectious diseases complicated by infections. Much less information is available concerning l-ficolin. We report the results of a prospective study to investigate any association between either MBL deficiency or l-ficolin deficiency with prematurity, low birthweight or perinatal infections in a large cohort of Polish neonates, representing an ethnically homogenous population (n=1832). Cord blood samples were analysed to determine mbl-2 gene variants, MBL concentrations and MBL-MASP-2 complex activities (MBL-dependent lectin pathway activity) as well as l-ficolin levels. Median concentrations of l-ficolin and MBL were 2500 and 1124 ng/ml, respectively, while median LP activity was 272 mU/ml. After genotyping, 60.6% of babies were mbl-2 A/A, 35.4% were A/O and 4% were O/O genotypes. We found relative l-ficolin deficiency to be associated with prematurity, low birthweight and infections. l-Ficolin concentration correlated with gestational age and with birthweight, independently of gestational age. Preterm deliveries (

Details

ISSN :
01615890
Volume :
46
Database :
OpenAIRE
Journal :
Molecular Immunology
Accession number :
edsair.doi.dedup.....1b5b0fe1593cecfa10ccf22504cf6904
Full Text :
https://doi.org/10.1016/j.molimm.2008.07.025