Back to Search
Start Over
Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates
- Source :
- Molecular Immunology. 46:551-558
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Ficolins and one collectin, mannan-binding lectin (MBL), are the only factors known to activate the lectin pathway (LP) of complement. There is considerable circumstantial evidence that MBL insufficiency can increase susceptibility to various infections and influence the course of several non-infectious diseases complicated by infections. Much less information is available concerning l-ficolin. We report the results of a prospective study to investigate any association between either MBL deficiency or l-ficolin deficiency with prematurity, low birthweight or perinatal infections in a large cohort of Polish neonates, representing an ethnically homogenous population (n=1832). Cord blood samples were analysed to determine mbl-2 gene variants, MBL concentrations and MBL-MASP-2 complex activities (MBL-dependent lectin pathway activity) as well as l-ficolin levels. Median concentrations of l-ficolin and MBL were 2500 and 1124 ng/ml, respectively, while median LP activity was 272 mU/ml. After genotyping, 60.6% of babies were mbl-2 A/A, 35.4% were A/O and 4% were O/O genotypes. We found relative l-ficolin deficiency to be associated with prematurity, low birthweight and infections. l-Ficolin concentration correlated with gestational age and with birthweight, independently of gestational age. Preterm deliveries (
- Subjects :
- Male
Genotype
Immunology
Population
chemical and pharmacologic phenomena
Biology
Mannose-Binding Lectin
Cohort Studies
Gene Frequency
Lectins
medicine
Humans
Genetic Predisposition to Disease
Prospective Studies
education
Prospective cohort study
Molecular Biology
Mannan-binding lectin
education.field_of_study
Bacteria
Infant, Newborn
Gestational age
Bacterial Infections
Complement System Proteins
Infant, Low Birth Weight
bacterial infections and mycoses
MBL deficiency
medicine.disease
Mannose-Binding Protein-Associated Serine Proteases
Lectin pathway
Cord blood
Female
Poland
Infant, Premature
Subjects
Details
- ISSN :
- 01615890
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Molecular Immunology
- Accession number :
- edsair.doi.dedup.....1b5b0fe1593cecfa10ccf22504cf6904
- Full Text :
- https://doi.org/10.1016/j.molimm.2008.07.025