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Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor: A 2-Year Outcome Study of Chinese People
- Source :
- Frontiers in Aging Neuroscience, Vol 13 (2021), Frontiers in Aging Neuroscience
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Background: Essential tremor (ET) is a common movement disorder among elderly individuals worldwide and is occasionally associated with a high risk for mild cognitive impairment and dementia. This retrospective study aimed to determine the clinical outcome of unilateral magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in Chinese patients with ET.Methods: In total, 31 male and 17 female patients with drug-refractory ET were enrolled in this research study from January 2017 to September 2019. The severity of tremor and disability were assessed using the Clinical Rating Scale for Tremor (CRST) within a 2-year follow-up period.Results: The mean age of the participants was 59.14 ± 13.5 years. The mean skull density ratio (SDR) was 0.5 ± 0.1. The mean highest temperature was 57.0 ± 2.4°C. The mean number of sonications was 10.0 ± 2.6. The average maximum energy was 19,710.5 ± 8,624.9 J. The total CRST scores and sub-scores after MRgFUS thalamotomy significantly reduced during each follow-up (p < 0.001). All but four (8.3%) of the patients had reversible adverse events (AEs) after the procedure.Conclusions: MRgFUS had sustained clinical efficacy 2 years after treatment for intractable ET. Only few patients presented with thalamotomy-related AEs including numbness, weakness, and ataxia for an extended period. Most Chinese patients were treated safely and effectively despite their low SDR.
- Subjects :
- Aging
Pediatrics
medicine.medical_specialty
Weakness
Ataxia
Cognitive Neuroscience
medicine.medical_treatment
Neurosciences. Biological psychiatry. Neuropsychiatry
03 medical and health sciences
0302 clinical medicine
Rating scale
medicine
Dementia
030212 general & internal medicine
essential tremor
Adverse effect
functional neurosurgery
Original Research
Essential tremor
business.industry
Thalamotomy
MR-guided focused ultrasound
Retrospective cohort study
thalamotomy
medicine.disease
focused ultrasound
medicine.symptom
business
030217 neurology & neurosurgery
Neuroscience
RC321-571
Subjects
Details
- ISSN :
- 16634365
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Frontiers in Aging Neuroscience
- Accession number :
- edsair.doi.dedup.....1b644f60dcf14e3179de9a4bf3b34ef3
- Full Text :
- https://doi.org/10.3389/fnagi.2021.697029