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A novel Foxp3-related immune prognostic signature for glioblastoma multiforme based on immunogenomic profiling
- Source :
- Aging (Albany NY)
- Publication Year :
- 2021
- Publisher :
- Impact Journals, 2021.
-
Abstract
- Foxp3+ regulatory T cells (Treg) play an important part in the glioma immunosuppressive microenvironment. This study analyzed the effect of Foxsp3 on the immune microenvironment and constructed a Foxp3-related immune prognostic signature (IPS)for predicting prognosis in glioblastoma multiforme (GBM). Immunohistochemistry (IHC) staining for Foxp3 was performed in 72 high-grade glioma specimens. RNA-seq data from 152 GBM samples were obtained from The Cancer Genome Atlas database (TCGA) and divided into two groups, Foxp3 High (Foxp3_H) and Foxp3 Low (Foxp3_L), based on Foxp3 expression. We systematically analyzed the influence of Foxp3 on the immune microenvironment. Least Absolute Shrinkage and Selection Operator (LASSO) Cox analysis was conducted for immune-related genes that were differentially expressed between Foxp3_H and Foxp3_L GBM patients. We found a differential expression of Foxp3 in high-grade glioma tissues. The presence of Foxp3 was significantly associated with poor OS. From the four-gene IPS developed, GBM patients were stratified into low-risk and high-risk groups in both the training set and validation sets. Furthermore, we developed a novel nomogram to evaluate the overall survival in GBM patients. This study offers innovative insights into the GBM immune microenvironment and these findings contribute to individualized treatment and improvement in the prognosis for GBM patients.
- Subjects :
- Male
Aging
chemical and pharmacologic phenomena
regulatory T cells
nomogram
glioblastoma multiforme
Immune system
Glioma
medicine
Tumor Microenvironment
Humans
RNA-Seq
Prognostic signature
business.industry
Brain Neoplasms
Gene Expression Profiling
FOXP3
Forkhead Transcription Factors
Cell Biology
Nomogram
Middle Aged
medicine.disease
Prognosis
nervous system diseases
immune prognostic signature
Survival Rate
Foxp3
Cancer research
Immunohistochemistry
Female
business
Glioblastoma
Transcriptome
Selection operator
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 19454589
- Volume :
- 13
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Aging (Albany NY)
- Accession number :
- edsair.doi.dedup.....1b81bd1024d22158dcb8c29a6dca7c9e