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External validation of the prognostic index in acute paraquat poisoning
- Source :
- Human & Experimental Toxicology. 35:366-370
- Publication Year :
- 2015
- Publisher :
- SAGE Publications, 2015.
-
Abstract
- Objective: Some studies have evaluated the prognostic indicators associated with acute paraquat (PQ) poisoning. In this study, we externally validated the Yamaguchi index, which showed a good prognostic relevance in predicting the outcome of PQ poisoning. Methods: A retrospective analysis of 297 patients was performed. The Yamaguchi index was calculated using the following equation: Eq1 = (K+ × HCO3−)/(Creatinine × 0.088)(mEq/L) against time from PQ ingestion ( T). The patients were divided into three groups: group A: Eq1 > 1500 − 399 × log T, group B: 930 − 399 × log T < Eq1 ≤ 1500 − 399 × log T, and group C: Eq1 ≤ 930 − 399 × log T). Results: The overall mortality rate was 65.3% (194 of 297). The mortality rates of the three groups stratified by the Yamaguchi index were 7.1% (2 of 28), 22.4% (15 of 67), and 87.6% (177 of 202). The area under the receiver–operating characteristic curve for predicting mortality from the external validation of the Yamaguchi index was 0.842 (95% confidence interval: 0.795–0.882). Conclusion: The Yamaguchi index is a reliable prognostic factor and could be helpful in predicting mortality due to PQ poisoning.
- Subjects :
- Paraquat
medicine.medical_specialty
Time Factors
Health, Toxicology and Mutagenesis
Toxicology
Severity of Illness Index
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Retrospective analysis
Humans
Hospital Mortality
030212 general & internal medicine
Retrospective Studies
Creatinine
business.industry
External validation
Reproducibility of Results
030208 emergency & critical care medicine
General Medicine
Prognosis
medicine.disease
PARAQUAT POISONING
Confidence interval
chemistry
Acute Disease
Medical emergency
business
Subjects
Details
- ISSN :
- 14770903 and 09603271
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Human & Experimental Toxicology
- Accession number :
- edsair.doi.dedup.....1b90e2c635b2cdc44517260f00f4bf51