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Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

Authors :
Cristina Fevola
Heidi C. Hauffe
Satu Mäkelä
Anne J. Jääskeläinen
Jukka Mustonen
Kristian M. Forbes
Antti Vaheri
Hannimari Kallio-Kokko
Niina Putkuri
Department of Virology
Medicum
Olli Pekka Vapalahti / Principal Investigator
Clinicum
Viral Zoonosis Research Unit
Source :
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 84
Publication Year :
2016

Abstract

Background: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. Objective: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity. Study design: We evaluated seroprevalence of and seroconversions to LCMV, LV and OPV in 116 patients hospitalized for NE. Clinical and laboratory variables were closely monitored during hospital care. Results: A total of five LCMV, 15 LV, and one OPV seroconversions occurred. NE patients with LCMV seroconversions were younger, and had lower plasma creatinine concentrations and platelet counts than patients without LCMV seroconversions. No differences occurred in clinical or laboratory findings between patients with and without seroconversions to LV and OPV. We report, for the first time, LCMV seroprevalence in Finland, with 8.5% of NE patients seropositive for this virus. Seroprevalences for LV and OPV were 47.8% and 32.4%, respectively. Conclusion: Cases with LCMV seroconversions were statistically younger, had milder acute kidney injury and more severe thrombocytopenia than patients without LCMV. However, the low number of seroconversion cases precludes firm conclusions. Concurrent LV or OPV infections do not appear to influence clinical picture for NE patients. (C) 2016 Elsevier B.V. All rights reserved.

Details

ISSN :
18735967
Volume :
84
Database :
OpenAIRE
Journal :
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Accession number :
edsair.doi.dedup.....1b96bdc43aed4b460f15d4504869d093