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Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection
- Source :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 84
- Publication Year :
- 2016
-
Abstract
- Background: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. Objective: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity. Study design: We evaluated seroprevalence of and seroconversions to LCMV, LV and OPV in 116 patients hospitalized for NE. Clinical and laboratory variables were closely monitored during hospital care. Results: A total of five LCMV, 15 LV, and one OPV seroconversions occurred. NE patients with LCMV seroconversions were younger, and had lower plasma creatinine concentrations and platelet counts than patients without LCMV seroconversions. No differences occurred in clinical or laboratory findings between patients with and without seroconversions to LV and OPV. We report, for the first time, LCMV seroprevalence in Finland, with 8.5% of NE patients seropositive for this virus. Seroprevalences for LV and OPV were 47.8% and 32.4%, respectively. Conclusion: Cases with LCMV seroconversions were statistically younger, had milder acute kidney injury and more severe thrombocytopenia than patients without LCMV. However, the low number of seroconversion cases precludes firm conclusions. Concurrent LV or OPV infections do not appear to influence clinical picture for NE patients. (C) 2016 Elsevier B.V. All rights reserved.
- Subjects :
- Male
Orthohantavirus
viruses
Parechovirus
Poxviridae Infections
Antibodies, Viral
Puumala virus
Zoonosis
0302 clinical medicine
Seroepidemiologic Studies
Zoonoses
Nephropathia epidemica
Lymphocytic choriomeningitis virus
030212 general & internal medicine
POPULATION
Finland
education.field_of_study
Coinfection
SEROPREVALENCE
virus diseases
Middle Aged
3. Good health
PREVALENCE
Europe
Infectious Diseases
Ljungan virus
WILD RODENTS
Seroconversion
Hemorrhagic Fever with Renal Syndrome
SEROLOGICAL SURVEY
Female
Adult
Orthopox virus
Puumala hantavirus
Cowpox
030231 tropical medicine
Population
MYOCARDITIS
VIRUS-INFECTION
Orthopoxvirus
Lymphocytic Choriomeningitis
Lymphocytic choriomeningitis
Virus
03 medical and health sciences
Virology
medicine
Seroprevalence
Animals
Humans
COWPOX
Settore VET/06 - PARASSITOLOGIA E MALATTIE PARASSITARIE DEGLI ANIMALI
education
Aged
Picornaviridae Infections
business.industry
medicine.disease
Immunology
ANTIBODIES
VOLES
3111 Biomedicine
business
Subjects
Details
- ISSN :
- 18735967
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
- Accession number :
- edsair.doi.dedup.....1b96bdc43aed4b460f15d4504869d093