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Limited Effect of Systemic β-Blockade on Sympathetic Outflow
- Source :
- Scopus-Elsevier
- Publication Year :
- 2001
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2001.
-
Abstract
- Central β-adrenoreceptors may augment sympathetic outflow. We tested the hypothesis that β-blockade attenuates central sympathetic outflow by inhibiting central adrenoreceptors. We studied 18 healthy controls (4 female, 14 male; age, 26±6 years, body mass index, 23±3 kg/m 2 ). ECG, brachial, and finger arterial blood pressure, muscle sympathetic nerve activity, and respiration were measured continuously before and during complete β-blockade. Subjects received a total intravenous dose of 0.21 mg/kg of propranolol in 15 minutes. Spontaneous baroreflex slopes were calculated using the sequence technique (BRSup, BRSdown). The sympathetic baroreflex slope was determined at baseline using phenylephrine and sodium nitroprusside infusions. The subjects underwent cold pressor testing before and during β-blockade. The R-R interval increased from 861±119 ms at baseline to 952±141 ms during β-blockade ( P P =NS). β-Blockade did not affect baroreflex sensitivity (BRSup: 21±10 versus 28±11 ms/mmHg, P P =NS). Muscle sympathetic nerve activity increased significantly during β-blockade (number of bursts/100 beats: 32±9 versus 40±14, P
- Subjects :
- Adult
Male
Nitroprusside
medicine.medical_specialty
Sympathetic nervous system
Sympathetic Nervous System
Adrenergic beta-Antagonists
Hemodynamics
Blood Pressure
Propranolol
Baroreflex
Electrocardiography
Phenylephrine
Reference Values
Internal medicine
Heart rate
Internal Medicine
medicine
Humans
business.industry
Muscles
Cold pressor test
Blood pressure
medicine.anatomical_structure
Endocrinology
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15244563 and 0194911X
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Hypertension
- Accession number :
- edsair.doi.dedup.....1b9c022c958e2c0caaede106143a10fd