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Clinical Characteristics and Treatment Response in Microscopic Colitis Based on Age at Diagnosis: A Multicenter Retrospective Study
- Source :
- Digestive diseases and sciences. 67(7)
- Publication Year :
- 2021
-
Abstract
- Microscopic colitis (MC) primarily affects older adults; thus, data in younger patients are scarce. To compare clinical characteristics and treatment response by age at diagnosis. This retrospective cohort study was performed at Mayo Clinic and Massachusetts General Hospital. Patients were chosen consecutively using established databases. Patients were ‘younger’ if age at diagnosis was ≤ 50 years and ‘older’ if age > 50 years. Treatment outcomes were captured for induction (12 ± 4 weeks), based on the total number of daily stools, and defined as remission (complete resolution), response (≥ 50% improvement), non-response ( 0.05). Younger patients were more likely to have celiac disease (17.3% vs. 5.8%, P = 0.01), while older patients had higher BMI (mean 25.0 vs. 23.8 kg/m2, P = 0.04) were more likely smokers (53.9% vs. 34.6%, P = 0.01) and use NSAIDs (48.6% vs. 15.4%, P
- Subjects :
- Budesonide
Colitis, Lymphocytic
medicine.medical_specialty
Lymphocytic colitis
Physiology
Colitis, Collagenous
Disease
Microscopic colitis
Internal medicine
medicine
Humans
Aged
Retrospective Studies
Collagenous colitis
business.industry
Gastroenterology
Age Factors
Retrospective cohort study
Hepatology
Middle Aged
medicine.disease
Colitis, Microscopic
Diarrhea
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 15732568
- Volume :
- 67
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Digestive diseases and sciences
- Accession number :
- edsair.doi.dedup.....1ba9987824fead051f01d6ef402a3716