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Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
- Source :
- Cell Metabolism, 34(2), 329-+. CELL PRESS, Cell Metab. 34, 329-345.e8 (2022), Sato, S, Dyar, K A, Treebak, J T, Jepsen, S L, Ehrlich, A M, Ashcroft, S P, Trost, K, Kunzke, T, Prade, V M, Small, L, Basse, A L, Schönke, M, Chen, S, Samad, M, Baldi, P, Barrès, R, Walch, A, Moritz, T, Holst, J J, Lutter, D, Zierath, J R & Sassone-Corsi, P 2022, ' Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis ', Cell Metabolism, vol. 34, no. 2, pp. 329-345.e8 . https://doi.org/10.1016/j.cmet.2021.12.016
- Publication Year :
- 2022
-
Abstract
- Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.
- Subjects :
- Mice
Liver
2-hydroxybutyrate
Arteriovenous Metabolomics
Circadian Rhythms
Exercise Metabolism
Exerkines
Metabolomics
Multitissue Analysis
Physiology
Circadian Clocks
Physical Conditioning, Animal
Animals
Homeostasis
Cell Biology
Molecular Biology
General Economics, Econometrics and Finance
Circadian Rhythm
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cell Metabolism, 34(2), 329-+. CELL PRESS, Cell Metab. 34, 329-345.e8 (2022), Sato, S, Dyar, K A, Treebak, J T, Jepsen, S L, Ehrlich, A M, Ashcroft, S P, Trost, K, Kunzke, T, Prade, V M, Small, L, Basse, A L, Schönke, M, Chen, S, Samad, M, Baldi, P, Barrès, R, Walch, A, Moritz, T, Holst, J J, Lutter, D, Zierath, J R & Sassone-Corsi, P 2022, ' Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis ', Cell Metabolism, vol. 34, no. 2, pp. 329-345.e8 . https://doi.org/10.1016/j.cmet.2021.12.016
- Accession number :
- edsair.doi.dedup.....1bb5cb05e541bd1b41ffcae156f39cb2
- Full Text :
- https://doi.org/10.1016/j.cmet.2021.12.016