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Patient-specific simulation of stent-graft deployment in type B aortic dissection: model development and validation
- Source :
- Biomechanics and Modeling in Mechanobiology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Thoracic endovascular aortic repair (TEVAR) has been accepted as the mainstream treatment for type B aortic dissection, but post-TEVAR biomechanical-related complications are still a major drawback. Unfortunately, the stent-graft (SG) configuration after implantation and biomechanical interactions between the SG and local aorta are usually unknown prior to a TEVAR procedure. The ability to obtain such information via personalised computational simulation would greatly assist clinicians in pre-surgical planning. In this study, a virtual SG deployment simulation framework was developed for the treatment for a complicated aortic dissection case. It incorporates patient-specific anatomical information based on pre-TEVAR CT angiographic images, details of the SG design and the mechanical properties of the stent wire, graft and dissected aorta. Hyperelastic material parameters for the aortic wall were determined based on uniaxial tensile testing performed on aortic tissue samples taken from type B aortic dissection patients. Pre-stress conditions of the aortic wall and the action of blood pressure were also accounted for. The simulated post-TEVAR configuration was compared with follow-up CT scans, demonstrating good agreement with mean deviations of 5.8% in local open area and 4.6 mm in stent strut position. Deployment of the SG increased the maximum principal stress by 24.30 kPa in the narrowed true lumen but reduced the stress by 31.38 kPa in the entry tear region where there was an aneurysmal expansion. Comparisons of simulation results with different levels of model complexity suggested that pre-stress of the aortic wall and blood pressure inside the SG should be included in order to accurately predict the deformation of the deployed SG.
- Subjects :
- Technology
Computed Tomography Angiography
medicine.medical_treatment
Engineering
0903 Biomedical Engineering
Aorta
Aortic dissection
TEVAR
Type B aortic dissection
Endovascular Procedures
Models, Cardiovascular
Finite element analysis
Patient specific
Modeling and Simulation
ENTRY
cardiovascular system
Female
Stents
Radiology
Life Sciences & Biomedicine
0913 Mechanical Engineering
Biotechnology
Adult
medicine.medical_specialty
Biophysics
Biomedical Engineering
Lumen (anatomy)
DIAGNOSIS
Blood Vessel Prosthesis Implantation
Virtual stent-graft deployment
medicine.artery
Alloys
medicine
Humans
Computer Simulation
Model development
Engineering, Biomedical
Original Paper
Science & Technology
business.industry
Mechanical Engineering
Reproducibility of Results
Stent
ENDOVASCULAR REPAIR
medicine.disease
Elasticity
Aortic wall
Aortic Dissection
Stress, Mechanical
business
Subjects
Details
- ISSN :
- 16177940 and 16177959
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Biomechanics and Modeling in Mechanobiology
- Accession number :
- edsair.doi.dedup.....1bb839944a3503923c76a4d5b858a559