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Comparison of hemodynamic changes after repetitive transcranial magnetic stimulation over the anatomical hand knob and hand motor hotspot: A functional near-infrared spectroscopy study
- Source :
- Restorative Neurology and Neuroscience
- Publication Year :
- 2020
-
Abstract
- Background: Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. Objective: The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) and the hand motor hotspot (hMHS) in the dominant motor cortex. Methods: Ten healthy right-handed participants without a history of neurological or psychiatric symptoms (five males; 29.8±2.8 years) participated in this single-blind, randomized, cross-over study. rTMS was applied under three conditions over the dominant (left) hemisphere for 20 minutes: 1) 1 Hz rTMS stimulation on the HK (HK-rTMS), 2) 1 Hz rTMS stimulation on the hMHS (hMHS-rTMS), and 3) sham stimulation (Sham-rTMS). For all participants, functional near-infrared spectroscopy (fNIRS) was applied for measurement of cerebral oxyhemoglobin (oxyHb) and deoxyhemoglobin (deoxyHb) concentration over the non-dominant (right) hemisphere during a serial reaction time task (SRTT) with the non-dominant (left) hand before and after each condition. Results: The average coordinates of the hMHS (x = – 39.60 mm, y = – 17.11 mm, z = 66.40 mm) were anterior and lateral to the HK (x = – 36.72 mm, y = – 28.87 mm, z = 56.41 mm). In fNIRS time-series analysis, the integral value of oxyHb was significantly increased over the motor cortical region of the non-dominant hemisphere after the hMHS-rTMS compared with Sham-rTMS. The HK-rTMS also showed slight increment of oxyHb concentration but without statistical significance. The SPM group analysis showed greater magnitude of the activity in hMHS-rTMS than that of HK-rTMS after stimulation (p
- Subjects :
- Serial reaction time
Adult
Male
medicine.medical_specialty
Modulation effect
medicine.medical_treatment
hand knob
Hemodynamics
Stimulation
Interhemispheric modulation
behavioral disciplines and activities
hand motor hot spot
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Developmental Neuroscience
Near-infrared spectroscopy
Internal medicine
mental disorders
Medicine
Humans
0501 psychology and cognitive sciences
Single-Blind Method
Cross-Over Studies
Spectroscopy, Near-Infrared
business.industry
musculoskeletal, neural, and ocular physiology
05 social sciences
Contralateral hemisphere
Motor Cortex
Evoked Potentials, Motor
Hand
Transcranial Magnetic Stimulation
Transcranial magnetic stimulation
medicine.anatomical_structure
Neurology
nervous system
Cardiology
Functional near-infrared spectroscopy
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
psychological phenomena and processes
Motor cortex
Research Article
Subjects
Details
- ISSN :
- 18783627
- Volume :
- 38
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Restorative neurology and neuroscience
- Accession number :
- edsair.doi.dedup.....1bbbd6c6e289422e70adb2e15528f540