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Androgen Receptor in Breast Cancer—Clinical and Preclinical Research Insights
- Source :
- Molecules, Vol 25, Iss 2, p 358 (2020), Molecules
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The Androgen Receptor (AR) is emerging as an important factor in the pathogenesis of breast cancer (BC), which is the most common malignancy among females worldwide. The concordance of more than 70% of AR expression in primary and metastatic breast tumors implies that AR may be a new marker and a potential therapeutic target among AR-positive breast cancer patients. Biological insight into AR-positive breast cancer reveals that AR may cross-talk with several vital signaling pathways, including key molecules and receptors. AR exhibits different behavior depending on the breast cancer subtype. Preliminary clinical research using AR-targeted drugs, which have already been FDA-approved for prostate cancer (PC), has given promising results for AR-positive breast cancer patients. However, since the prognostic and predictive value of AR positivity remains uncertain, it is difficult to identify and stratify patients that would benefit from AR-targeted therapies. Herein, through a review of preclinical studies, clinical studies, and clinical trials, we summarize the biology of AR, its prognostic and predictive value, as well as its therapeutic implications by breast cancer molecular subtype.
- Subjects :
- Oncology
antiandrogens
medicine.medical_specialty
Drug Evaluation, Preclinical
Pharmaceutical Science
Estrogen receptor
Antineoplastic Agents
Breast Neoplasms
Review
Malignancy
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Breast cancer
breast cancer
lcsh:Organic chemistry
Internal medicine
androgen receptor
Drug Discovery
Animals
Humans
Medicine
Molecular Targeted Therapy
Physical and Theoretical Chemistry
Triple-negative breast cancer
030304 developmental biology
0303 health sciences
business.industry
Organic Chemistry
androgens
medicine.disease
3. Good health
Clinical trial
Androgen receptor
Clinical research
Receptors, Androgen
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
triple negative breast cancer
Molecular Medicine
Female
business
Signal Transduction
estrogen receptor
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....1bbc2793358cc52abf57acfeb5ee4b7a