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Contrasting patterns of tolerance between chemical and biological insecticides in mosquitoes exposed to UV-A
- Source :
- Aquatic Toxicology, Aquatic Toxicology, 2013, 140-141, pp.389-397, Aquatic Toxicology, Elsevier, 2013, 140-141, pp.389-397
- Publication Year :
- 2013
-
Abstract
- Mosquitoes are vectors of major human diseases, such as malaria, dengue or yellow fever. Because no efficient treatments or vaccines are available for most of these diseases, control measures rely mainly on reducing mosquito populations by the use of insecticides. Numerous biotic and abiotic factors are known to modulate the efficacy of insecticides used in mosquito control. Mosquito breeding sites vary from opened to high vegetation covered areas leading to a large ultraviolet gradient exposure. This ecological feature may affect the general physiology of the insect, including the resistance status against insecticides. In the context of their contrasted breeding sites, we assessed the impact of low-energetic ultraviolet exposure on mosquito sensitivity to biological and chemical insecticides. We show that several mosquito detoxification enzyme activities (cytochrome P450, glutathione S-transferases, esterases) were increased upon low-energy UV-A exposure. Additionally, five specific genes encoding detoxification enzymes (CYP6BB2, CYP6Z7, CYP6Z8, GSTD4, and GSTE2) previously shown to be involved in resistance to chemical insecticides were found over-transcribed in UV-A exposed mosquitoes, revealed by RT-qPCR experiments. More importantly, toxicological bioassays revealed that UV-exposed mosquitoes were more tolerant to four main chemical insecticide classes (DDT, imidacloprid, permethrin, temephos), whereas the bioinsecticide Bacillus thuringiensis subsp. israelensis (Bti) appeared more toxic. The present article provides the first experimental evidence of the capacity of low-energy UV-A to increase mosquito tolerance to major chemical insecticides. This is also the first time that a metabolic resistance to chemical insecticides is linked to a higher susceptibility to a bioinsecticide. These results support the use of Bti as an efficient alternative to chemical insecticides when a metabolic resistance to chemicals has been developed by mosquitoes.
- Subjects :
- [SDE] Environmental Sciences
Insecticides
Pesticide resistance
Ultraviolet Rays
Health, Toxicology and Mutagenesis
[SDV]Life Sciences [q-bio]
030231 tropical medicine
Context (language use)
Aedes aegypti
Aquatic Science
Biology
Toxicology
Insecticide Resistance
03 medical and health sciences
0302 clinical medicine
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
parasitic diseases
medicine
Animals
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
0303 health sciences
fungi
Neonicotinoid
Pesticide
biology.organism_classification
3. Good health
[SDV] Life Sciences [q-bio]
Enzyme Activation
Biopesticide
Mosquito control
Culicidae
Gene Expression Regulation
Larva
[SDE]Environmental Sciences
[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Cytochromes
Permethrin
medicine.drug
Subjects
Details
- ISSN :
- 18791514 and 0166445X
- Database :
- OpenAIRE
- Journal :
- Aquatic toxicology (Amsterdam, Netherlands)
- Accession number :
- edsair.doi.dedup.....1bc35ae5406684905e66883dae0ec07d