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Shared class II MHC polymorphisms between humans and chimpanzees
- Source :
- Human Immunology. 26:107-121
- Publication Year :
- 1989
- Publisher :
- Elsevier BV, 1989.
-
Abstract
- To gain an insight into the evolution of the major histocompatibility complex alleles, three DRB and one DRA genes were isolated from chimpanzee cDNA libraries. The nucleotide sequences of the chimpanzee DRB (ChLA-DRB) genes were then compared with those of the available HLA-DRB alleles by constructing unrooted phylogenetic trees. All three ChLA-DRB genes were found to be more closely related to certain HLA-DRB alleles than unrelated HLA-DRB alleles are to each other. Since available evidence does not support the convergent evolution of MHC alleles, this result is consistent with the idea that closely related ChLA-DRB and HLA-DRB alleles are derived from common ancestral alleles, the existence of which predates the divergence of human and chimpanzee lineages. The predicted amino acid sequences of mature ChLA-DRA and HLA-DRA molecules differ by only one amino acid.
- Subjects :
- Pan troglodytes
Genes, MHC Class II
Molecular Sequence Data
Immunology
Biology
Major histocompatibility complex
Molecular evolution
Phylogenetics
Convergent evolution
Animals
Humans
Immunology and Allergy
Amino Acid Sequence
Allele
Codon
Gene
Phylogeny
Cell Line, Transformed
Gene Library
Genetics
Polymorphism, Genetic
Base Sequence
Phylogenetic tree
DNA
HLA-DR Antigens
General Medicine
Histocompatibility
biology.protein
DNA Probes
Subjects
Details
- ISSN :
- 01988859
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Human Immunology
- Accession number :
- edsair.doi.dedup.....1bdf70509df66d981c2888b07e1150c2