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Penetration of sulbactam and ampicillin into cerebrospinal fluid of infants and young children with meningitis
- Source :
- Antimicrobial Agents and Chemotherapy. 31:1703-1705
- Publication Year :
- 1987
- Publisher :
- American Society for Microbiology, 1987.
-
Abstract
- Infusions of 50 mg of sulbactam per kg per day and 400 mg of ampicillin per kg per day in divided doses to infants and children with bacterial meningitis produced levels in cerebrospinal fluid approximately one-third those in serum. Concentrations in cerebrospinal fluid of 5.5 micrograms of sulbactam per ml and 16.0 micrograms of ampicillin per ml declined within a few days of therapy to 1.9 microgram of sulbactam per ml and 5.2 micrograms of ampicillin per ml.
- Subjects :
- Adolescent
medicine.drug_class
Antibiotics
Permeability
Cerebrospinal fluid
Pharmacokinetics
Ampicillin
polycyclic compounds
Humans
Medicine
Meningitis
Pharmacology (medical)
Child
Pharmacology
business.industry
Infant
Sulbactam
biochemical phenomena, metabolism, and nutrition
medicine.disease
Infectious Diseases
Child, Preschool
Anesthesia
Bacterial meningitis
business
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....1bfc7fc8be135afe3722422afa73d984