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Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction
- Source :
- Inflammation. 30(3-4)
- Publication Year :
- 2007
-
Abstract
- The aim of the present study was to investigate the role of anti-inflammation for MSCs transplantation in rat models of myocardial infarction. Rats with AMI induced by occlusion of the left coronary artery were randomized to MSCs transplantation group, MI group and sham operated group. The effects of MSCs transplantation on cardiac inflammation and left ventricular remodeling in non-infarcted zone were observed after 4 weeks of MI. We found that MSC transplantation (1) decreased protein production and gene expression of inflammation cytokines TNF-alpha, IL-1beta and IL-6, (2) inhibited deposition of type I and III collagen, as well as gene and protein expression of MMP-1 and TIMP-1, (3) attenuated LV cavitary dilation and transmural infarct thinning, thus prevent myocardial remodeling after myocardial infarction, and (4) increased EF, FS, LVESP and dp/dtmax (P < 0.01), decreased LVDd, LVEDV, LVEDP (P < 0.05). Anti-inflammation role for MSCs transplantation might partly account for the cardiac protective effect in ischemic heart disease.
- Subjects :
- Male
medicine.medical_specialty
Immunology
Interleukin-1beta
Myocardial Infarction
Gene Expression
Inflammation
Mesenchymal Stem Cell Transplantation
Collagen Type I
Muscle hypertrophy
Rats, Sprague-Dawley
Left coronary artery
Internal medicine
medicine.artery
medicine
Immunology and Allergy
Animals
Myocardial infarction
Ventricular remodeling
Tissue Inhibitor of Metalloproteinase-1
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Myocardium
Mesenchymal stem cell
Mesenchymal Stem Cells
medicine.disease
Rats
Transplantation
Preload
Myocarditis
Collagen Type III
Echocardiography
Cardiology
Hypertrophy, Left Ventricular
medicine.symptom
Matrix Metalloproteinase 1
business
Subjects
Details
- ISSN :
- 03603997
- Volume :
- 30
- Issue :
- 3-4
- Database :
- OpenAIRE
- Journal :
- Inflammation
- Accession number :
- edsair.doi.dedup.....1bfd679a0a413a5ea0563d8dd6a04568