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Augmented myeloablative conditioning with thiotepa in acute myeloid leukemia – improved outcomes with similar toxicity
- Source :
- Leukemia & Lymphoma. 60:726-733
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Myeloablative doses of busulfan (Bu) with fludarabine (Flu) have reduced toxicity, however, limited by an increased relapse rate. We aimed to improve outcome of Flu-Bu regimen by augmentation with thiotepa (TT) (10 mg/kg). Eighty-nine patients with AML, 44 patients conditioned with Flu-Bu (group 1), and 45 patients augmented with TT (Flu-Bu-TT, group 2), were retrospectively analyzed. Primary objectives were toxicity and outcomes. Major toxicities were comparable: mucositis (p = 1.0), sepsis (p = .7), severe venocclusive disease of liver (VOD) (p = 1.0), and non-relapse mortality (NRM) (22 vs. 22%, p = .7). Five-year disease-free survival was significantly better in group 2 compared to group 1 (62 vs. 38%, p = .02). Five-year overall survival (OS) showed trend toward benefit in group 2 (62 vs. 42%, p = .06). Lower relapse rate in group 2 (14 vs. 46%, p = .005) contributed to better outcomes. Augmented regimen has better disease-free survival (DFS) (mainly due to reduced relapse rate) and similar toxicities as compared to Flu-Bu. Key points Assessing the addition of TT to myeloablative conditioning (Flu, Bu) in patients undergoing allogeneic stem cell transplant for acute myeloid leukemia with regard to relapse rate, disease-free survival and toxicity. Addition of thiotepa improves disease-free survival and shows trend toward benefit in overall survival, by reducing relapses without additional toxicity.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Transplantation Conditioning
Adolescent
Graft vs Host Disease
ThioTEPA
Sepsis
Young Adult
03 medical and health sciences
0302 clinical medicine
Recurrence
Internal medicine
medicine
Mucositis
Humans
Transplantation, Homologous
business.industry
Graft Survival
Hematopoietic Stem Cell Transplantation
Myeloid leukemia
Hematology
Myeloablative Agonists
medicine.disease
Fludarabine
Leukemia, Myeloid, Acute
Regimen
Treatment Outcome
030220 oncology & carcinogenesis
Toxicity
Female
business
Thiotepa
Busulfan
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....1c083a718a572c0bc518cec27ca0cb10