Design and Synthesis of Telomestatin Derivatives and Their Inhibitory Activity of Telomerase

Authors :: Takayuki Doi
Yoshihiro Sohtome
Masayuki Tera
Hiromichi Ishizuka
Kazuo Shin-ya
Motoki Takagi
Kazuo Nagasawa
Source :: Heterocycles. 69:505-514
Publication Year :: 2006
Abstract: Telomestatin derivatives of 2a-2c, which have macrocyclic bisamide structure, were designed and synthesized. One of these compounds (2a) showed inhibitory activity of telomerase with an IC 50 of 2 μM.

Subjects :: Pharmacology
Telomerase
chemistry.chemical_compound
chemistry
Stereochemistry
Organic Chemistry
Telomerase Inhibitor
Structure–activity relationship
Inhibitory postsynaptic potential
Telomestatin
Analytical Chemistry

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