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Construction of Chiral Tri- and Tetra-Arylmethanes Bearing Quaternary Carbon Centers: Copper-Catalyzed Enantioselective Propargylation of Indoles with Propargylic Esters

Authors :
Kazunari Nakajima
Yasushi Senda
Kouhei Tsuchida
Yoshiaki Nishibayashi
Source :
Angewandte Chemie (International ed. in English). 55(33)
Publication Year :
2016

Abstract

Copper-catalyzed enantioselective propargylation of indoles with propargylic esters and sequential Huisgen cycloaddition with azides lead to the construction of chiral triarylmethanes, bearing a quaternary carbon center, with high to excellent enantioselectivities. The result described herein can be used in the enantioselective preparation of a tetraarylmethane.

Details

ISSN :
15213773
Volume :
55
Issue :
33
Database :
OpenAIRE
Journal :
Angewandte Chemie (International ed. in English)
Accession number :
edsair.doi.dedup.....1c17707b7a13982c6babd75f0ccbf02c