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A robust bacterial high-throughput screening system to evaluate single nucleotide polymorphisms of human homogentisate 1,2-dioxygenase in the context of alkaptonuria
- Source :
- Scientific reports 12, 19452 (2022). doi:10.1038/s41598-022-23702-y
- Publication Year :
- 2022
- Publisher :
- RWTH Aachen University, 2022.
-
Abstract
- Scientific reports 12, 19452 (2022). doi:10.1038/s41598-022-23702-y<br />Published by Macmillan Publishers Limited, part of Springer Nature, [London]
- Subjects :
- Biochemistry, medical
Homogentisate 1,2-Dioxygenase
Multidisciplinary
Alkaptonuria
Polymorphism, Single Nucleotide
Dioxygenases
High-Throughput Screening Assays
Escherichia coli/genetics
Pharmacology, Toxicology and Pharmaceutics(all)
hepatology
Alkaptonuria/genetics
Drug Discovery
Escherichia coli
Humans
genetics
Dioxygenases/genetics
Homogentisic Acid
ddc:600
Homogentisate 1,2-Dioxygenase/genetics
biotechnology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientific reports 12, 19452 (2022). doi:10.1038/s41598-022-23702-y
- Accession number :
- edsair.doi.dedup.....1c1da732e8053b3f4121eecd00fdb6d8
- Full Text :
- https://doi.org/10.18154/rwth-2022-11788