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Bmp8a is an essential positive regulator of antiviral immunity in zebrafish
- Source :
- Communications Biology, Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
- Publication Year :
- 2020
-
Abstract
- Bone morphogenetic protein (BMP) is a kind of classical multi-functional growth factor that plays a vital role in the formation and maintenance of bone, cartilage, muscle, blood vessels, and the regulation of adipogenesis and thermogenesis. However, understanding of the role of BMPs in antiviral immunity is still limited. Here we demonstrate that Bmp8a is a newly-identified positive regulator for antiviral immune responses. The bmp8a−/− zebrafish, when infected with viruses, show reduced antiviral immunity and increased viral load and mortality. We also show for the first time that Bmp8a interacts with Alk6a, which promotes the phosphorylation of Tbk1 and Irf3 through p38 MAPK pathway, and induces the production of type I interferons (IFNs) in response to viral infection. Our study uncovers a previously unrecognized role of Bmp8a in regulation of antiviral immune responses and provides a target for controlling viral infection.<br />Zhang, Liu and colleagues identify the role of Bmp8a in antiviral immunity in zebrafish and provide mechanistic insight into its function. Bmp8a could serve as a future target for investigative studies of antiviral immune responses.
- Subjects :
- 0301 basic medicine
QH301-705.5
animal diseases
Regulator
Medicine (miscellaneous)
chemical and pharmacologic phenomena
Biology
Protein Serine-Threonine Kinases
Bone morphogenetic protein
Virus Replication
p38 Mitogen-Activated Protein Kinases
General Biochemistry, Genetics and Molecular Biology
Article
Animals, Genetically Modified
03 medical and health sciences
Gene Knockout Techniques
0302 clinical medicine
Immune system
Animals
Bone morphogenetic protein receptor
Biology (General)
Phosphorylation
Zebrafish
Bone Morphogenetic Protein Receptors, Type I
biochemical phenomena, metabolism, and nutrition
Viral Load
Zebrafish Proteins
biology.organism_classification
Cell biology
030104 developmental biology
Retroviridae
Viral replication
Bone Morphogenetic Proteins
Host-Pathogen Interactions
Interferon Type I
RIG-I-like receptors
bacteria
Interferon Regulatory Factor-3
General Agricultural and Biological Sciences
IRF3
Infection
Viral load
030215 immunology
Retroviridae Infections
Signal Transduction
Subjects
Details
- ISSN :
- 23993642
- Volume :
- 4
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Communications biology
- Accession number :
- edsair.doi.dedup.....1c32ba22be97c2e46adac8b11854382b