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Dose-response relationship between treatment delay of smear-positive tuberculosis patients and intra-household transmission: a cross-sectional study
- Source :
- Transactions of the Royal Society of Tropical Medicine and Hygiene. 102(8)
- Publication Year :
- 2007
-
Abstract
- In order to document the effect of treatment delay on tuberculosis (TB) latent infection among the household contacts of TB patients, a cross-sectional TB infection prevalence survey was conducted among household contacts in Yunnan Province, southern China. In total, 1360 household contacts of 393 smear-positive pulmonary TB patients were enrolled, together with 308 household contacts of 90 non-TB patients. Using the contacts of non-TB patients as the baseline of TB infection, there was a dose-response relationship between household infection and delay of TB treatment (TB infection prevalence 9.7, 7.8, 19.9, 25.7 and 26.9% for non-TB case, TB case with delayor =30 d, 30-60 d, 60-90 d and90 d, respectively). Older age, TB index patient with lung cavitation, and sleeping in the same bedroom with a TB patient were all associated with an increased risk of being tuberculin-skin-test positive. In conclusion, 30 d delay in treatment seems to be the turning point at which a significant increase in risk for TB infection occurs. Apart from conventional indicators, magnitude of treatment delay should be considered as a performance indicator for TB control programmes in high-TB-burden countries. Measures for the detection of early cases should be intensified.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pediatrics
China
Tuberculosis
Time Factors
Cross-sectional study
law.invention
Age Distribution
law
Risk Factors
medicine
Humans
Tuberculosis, Pulmonary
Family Characteristics
Dose-Response Relationship, Drug
business.industry
Infection prevalence
Public Health, Environmental and Occupational Health
Sputum
Treatment delay
General Medicine
Mycobacterium tuberculosis
Middle Aged
medicine.disease
Surgery
Infectious Diseases
Transmission (mechanics)
Cross-Sectional Studies
Early Diagnosis
Southern china
Socioeconomic Factors
Tropical medicine
Parasitology
Female
Contact Tracing
business
Contact tracing
Subjects
Details
- ISSN :
- 00359203
- Volume :
- 102
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Accession number :
- edsair.doi.dedup.....1c3445591308c3aa49a861aa1cefca68