Associations Between Metabolic Syndrome And Bone Mineral Density And Trabecular Bone Score In Postmenopausal Women With Non-Vertebral Fractures

Medical, social, and economic relevance of osteoporosis is caused by reducing quality of life, increasing disability and mortality of the patients as a result of fractures due to the low-energy trauma. This study is aimed to examine the associations of metabolic syndrome components, bone mineral density (BMD) and trabecular bone score (TBS) in menopausal women with non-vertebral fractures. 1161 menopausal women aged 50-79 year-old were examined and divided into three groups: A included 419 women with increased body weight (BMI - 25.0-29.9 kg/m2), B – 442 females with obesity (BMI >29.9 kg/m2)i and C – 300 women with metabolic syndrome (diagnosis according to IDF criteria, 2005). BMD of lumbar spine (L1-L4), femoral neck, total body and forearm was investigated with usage of dual-energy X-ray absorptiometry. The bone quality indexes were measured according to Med-Imaps installation. All analyses were performed using Statistical Package 6.0. BMD of lumbar spine (L1-L4), femoral neck, total body, and ultradistal radius was significant higher in women with obesity and metabolic syndrome compared to the pre-obese ones (p
{"references":["Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR. 'Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women', JAMA, 301:513–521, 2009; doi: 10.1001/jama.2009.50.","Dennison E.M., Syddall H.E., Aihie Sayer A., Martin H.J., Cooper C. Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study. QJM: An International Journal of Medicine, Volume 100, Issue 5, 1 May 2007, Pages 297–303, https://doi.org/10.1093/qjmed/hcm023. (Accessed on 09/01/2018, open access).","Didier Hans, Andrew L Goertzen, Marc-Antoine Krieg, William D Leslie. \"Bone Microarchitecture Assessed by TBS Predicts Osteoporotic Fractures Independent of Bone Density: The Manitoba Study\", Journal of Bone and Mineral Research, Vol. 26, No. 11, November 2011, pp 2762–2769/ DOI: 10.1002/jbmr.499.","Gonelli S., Caffarelli C., Nuti R. \"Obesity and fracture risk\" Clin. Cases Miner. Bone Metab., Jan; 11 (1): 9-14, 2014.","Huang CY, Liao LC, Tong KM, Lai HL, Chen WK, Chen CI, Lu CY, Chen FJ. Mediating effects on health-related quality of life in adults with osteoporosis: a structural equation modeling. Osteoporos. Int. 2015; 26(3):875–883. doi: 10.1007/s00198-014-2963-3.мс.","International Diabetes Federation. Worldwide definition of the metabolic syndrome. Available at: http: //WWW.idf.org/web-data/docs/IDF Metasyndrome definition. pdf. Accessed, August 24, 2005.","Kan Sun; Jianmin Liu; Nan Lu; Hanxiao Sun; Guang Ning \"Association between metabolic syndrome and bone fractures: a meta-analysis of observational studies,\" BMC Endocr Disord.; 14(13), 2014, Published online 2014 Feb 9. doi 10.1186/1472-6823-14-13.","Maghraoui A1, Rezqi A, Mrahi S, Sadni S, Ghozlani I, Mounach A. \"Osteoporosis, vertebral fractures and metabolic syndrome in postmenopausal women\" BMC Endocr Disord., Dec 10;14:93, 2014; doi: 10.1186/1472-6823-14-93.","Von Muhlen D, Safii S, Jassal SK, Svartberg J, Barrett-Connor E. Associations between the metabolic syndrome and bone health in older men and women: The Rancho Bernardo Study. Osteoporos Int. 2007; 18:1337–1344. doi: 10.1007/s00198-007-0385-1.\n[10]\tOfficial Positions of the International Society for Clinical Densitometry, Copyright ISCD, October 2007, Supersedes all prior \"Official Positions\" publications.\n[11]\tPoiana C, Carsote M, Radoi V, Mihai A, Capatina C. \"Prevalent osteoporotic fractures in 622 obese and non- obese menopausal women\", J Med Life, Oct-Dec; 8(4): 462–466, 2015.\n[12]\tSun K, Liu J, Lu N, Sun H, Ning G. Association between metabolic syndrome and bone fractures: a meta-analysis of observational studies. BMC Endocr Disord. 2014 Feb 9;14:13. doi: 10.1186/1472-6823-14-13. \n[13]\tSusan M. Ott. \"Bone strength: more just density\", Kidney International, 89; p.16-19, 2016.\n[14]\tTaulant Muka, Katerina Trajanoska, Jessica C. Kiefte-de Jong, Ling Oei, et al. The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study. Published: June 12, 2015, https://doi.org/10.1371/journal.pone.0129116. (Accessed on 09/01/2018, open access).\n[15]\tWorld Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity. World Health Organization: Geneva, 2000, р.9.\n[16]\tYang L, Lv X, Wei D, Yue F, Guo J, Zhang T. \"Metabolic syndrome and the risk of bone fractures: A Meta-analysis of prospective cohort studies\", Bone, Mar; 84:52-6, 2016; doi: 10.1016/j.bone.2015.12.008. Epub 2015 Dec 18."]}