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Presence of Recombinant Bat Coronavirus GCCDC1 in Cambodian Bats
- Source :
- Viruses, Viruses, 2022, 14 (2), pp.176. ⟨10.3390/v14020176⟩
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- International audience; Bats have been recognized as an exceptional viral reservoir, especially for coronaviruses. At least three bat zoonotic coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) have been shown to cause severe diseases in humans and it is expected more will emerge. One of the major features of CoVs is that they are all highly prone to recombination. An extreme example is the insertion of the P10 gene from reoviruses in the bat CoV GCCDC1, first discovered in Rousettus leschenaultii bats in China. Here, we report the detection of GCCDC1 in four different bat species (Eonycteris spelaea, Cynopterus sphinx, Rhinolophus shameli and Rousettus sp.) in Cambodia. This finding demonstrates a much broader geographic and bat species range for this virus and indicates common cross-species transmission. Interestingly, one of the bat samples showed a co-infection with an Alpha CoV most closely related to RsYN14, a virus recently discovered in the same genus (Rhinolophus) of bat in Yunnan, China, 2020. Taken together, our latest findings highlight the need to conduct active surveillance in bats to assess the risk of emerging CoVs, especially in Southeast Asia.
- Subjects :
- Recombination, Genetic
China
Coronaviridae
Coronaviridae Infections
[SDV]Life Sciences [q-bio]
viruses
bats
coronavirus
virus diseases
cross-species transmission
Genome, Viral
zoonosis
recombination
respiratory tract diseases
Evolution, Molecular
Phylogeography
co-infection
Infectious Diseases
Chiroptera
Virology
Animals
GCCDC1
Cambodia
Phylogeny
Disease Reservoirs
Subjects
Details
- ISSN :
- 19994915
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....1c3e71bbd5430f5a9c2774262d294bc5