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The PB2-K627E mutation attenuates H3N2 swine influenza virus in cultured cells and in mice

Authors :
Hao Zheng
Guangzhi Tong
Bao-Yang Ruan
Xiao-Min Liu
Wu Tong
Hai Yu
Guoxin Li
Peng Zhang
Xiu-Hui Wang
Yan-Jun Zhou
Xiao-Qian Gong
Qi Wang
Shan Tongling
Source :
Research in Veterinary Science. 117:54-56
Publication Year :
2018
Publisher :
Elsevier BV, 2018.

Abstract

PB2-627K is an important amino acid that determines the virulence of some influenza A viruses. However, it has not been experimentally investigated in the H3N2 swine influenza virus. To explore the potential role of PB2-K627E substitution in H3N2 swine influenza virus, the growth properties and pathogenicity between H3N2 swine influenza virus and its PB2-K627E mutant were compared. For the first time, our results showed that PB2-K627E mutation attenuates H3N2 swine influenza virus in mammalian cells and in mice, suggesting that PB2-627K is required for viral replication and pathogenicity of H3N2 swine influenza virus.

Details

ISSN :
00345288
Volume :
117
Database :
OpenAIRE
Journal :
Research in Veterinary Science
Accession number :
edsair.doi.dedup.....1c4157322119d01df85eb3a51ade5865
Full Text :
https://doi.org/10.1016/j.rvsc.2017.11.006