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Genome‐wide association for milk production and lactation curve parameters in Holstein dairy cows
- Source :
- Atashi, H, Salavati, M, De Koster, J, Ehrlich, J, Crowe, M, Opsomer, G, GplusE Consortium & Hostens, M 2020, ' Genome-wide association for milk production and lactation curve parameters in Holstein dairy cows ', Journal of Animal Breeding and Genetics, vol. 137, no. 3, pp. 292-304 . https://doi.org/10.1111/jbg.12442, JOURNAL OF ANIMAL BREEDING AND GENETICS, Journal of Animal Breeding and Genetics, Journal of Animal Breeding and Genetics, 137(3), 292. Wiley-Blackwell, Atashi, H, Salavati, M, De Koster, J, Ehrlich, J, Crowe, M A, Opsomer, G, The GplusE consortium & Hostens, M 2019, ' Genome-wide association for milk production and lactation curve parameters in Holstein dairy cows ', Journal of Animal Breeding and Genetics . https://doi.org/10.1111/jbg.12442
- Publication Year :
- 2020
-
Abstract
- The aim of this study was to identify genomic regions associated with 305‐day milk yield and lactation curve parameters on primiparous (n = 9,910) and multiparous (n = 11,158) Holstein cows. The SNP solutions were estimated using a weighted single‐step genomic BLUP approach and imputed high‐density panel (777k) genotypes. The proportion of genetic variance explained by windows of 50 consecutive SNP (with an average of 165 Kb) was calculated, and regions that accounted for more than 0.50% of the variance were used to search for candidate genes. Estimated heritabilities were 0.37, 0.34, 0.17, 0.12, 0.30 and 0.19, respectively, for 305‐day milk yield, peak yield, peak time, ramp, scale and decay for primiparous cows. Genetic correlations of 305‐day milk yield with peak yield, peak time, ramp, scale and decay in primiparous cows were 0.99, 0.63, 0.20, 0.97 and −0.52, respectively. The results identified three windows on BTA14 associated with 305‐day milk yield and the parameters of lactation curve in primi‐ and multiparous cows. Previously proposed candidate genes for milk yield supported by this work include GRINA, CYHR1, FOXH1, TONSL, PPP1R16A, ARHGAP39, MAF1, OPLAH and MROH1, whereas newly identified candidate genes are MIR2308, ZNF7, ZNF34, SLURP1, MAFA and KIFC2 (BTA14). The protein lipidation biological process term, which plays a key role in controlling protein localization and function, was identified as the most important term enriched by the identified genes.
- Subjects :
- Candidate gene
Genotype
QTL
CATTLE
PREDICTIONS
Genome-wide association study
Biology
Best linear unbiased prediction
Quantitative trait locus
Protein lipidation
Polymorphism, Single Nucleotide
milk yield
Animal science
Food Animals
Pregnancy
Lactation
Genetic variation
medicine
Animals
Veterinary Sciences
PERSISTENCY
genome‐wide association study
QUANTITATIVE TRAIT LOCI
Genome
GENETIC-PARAMETERS
genome-wide association study
Holstein
General Medicine
Original Articles
SOMATIC-CELL SCORE
Dairying
Parity
medicine.anatomical_structure
Milk
Phenotype
YIELD
Yield (chemistry)
Cattle
Female
Original Article
SHAPE
Animal Science and Zoology
ENRICHMENT
lactation curve
Subjects
Details
- Language :
- English
- ISSN :
- 09312668 and 14390388
- Database :
- OpenAIRE
- Journal :
- Atashi, H, Salavati, M, De Koster, J, Ehrlich, J, Crowe, M, Opsomer, G, GplusE Consortium & Hostens, M 2020, ' Genome-wide association for milk production and lactation curve parameters in Holstein dairy cows ', Journal of Animal Breeding and Genetics, vol. 137, no. 3, pp. 292-304 . https://doi.org/10.1111/jbg.12442, JOURNAL OF ANIMAL BREEDING AND GENETICS, Journal of Animal Breeding and Genetics, Journal of Animal Breeding and Genetics, 137(3), 292. Wiley-Blackwell, Atashi, H, Salavati, M, De Koster, J, Ehrlich, J, Crowe, M A, Opsomer, G, The GplusE consortium & Hostens, M 2019, ' Genome-wide association for milk production and lactation curve parameters in Holstein dairy cows ', Journal of Animal Breeding and Genetics . https://doi.org/10.1111/jbg.12442
- Accession number :
- edsair.doi.dedup.....1c5b3b3fe6eb5ea6154ec7d75abb723d