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NADPH Oxidase NOX4 Is a Critical Mediator of BRAFV600E-Induced Downregulation of the Sodium/Iodide Symporter in Papillary Thyroid Carcinomas
- Source :
- Antioxidants and Redox Signaling, Antioxidants and Redox Signaling, Mary Ann Liebert, 2017, 26 (15), pp.864-877. ⟨10.1089/ars.2015.6616⟩
- Publication Year :
- 2017
- Publisher :
- Mary Ann Liebert Inc, 2017.
-
Abstract
- Aims: The BRAFV600E oncogene, reported in 40%–60% of papillary thyroid cancer (PTC), has an important role in the pathogenesis of PTC. It is associated with the loss of thyroid iodide-metabolizing genes, such as sodium/iodide symporter (NIS), and therefore with radioiodine refractoriness. Inhibition of mitogen-activated protein kinase (MAPK) pathway, constitutively activated by BRAFV600E, is not always efficient in resistant tumors suggesting that other compensatory mechanisms contribute to a BRAFV600E adaptive resistance. Recent studies pointed to a key role of transforming growth factor β (TGF-β) in BRAFV600E-induced effects. The reactive oxygen species (ROS)-generating NADPH oxidase NOX4, which is increased in PTC, has been identified as a new key effector of TGF-β in cancer, suggestive of a potential role in BRAFV600E-induced thyroid tumors. Results: Here, using two human BRAFV600E-mutated thyroid cell lines and a rat thyroid cell line expressing BRAFV600E in a conditional manner, we show tha...
- Subjects :
- 0301 basic medicine
Sodium-iodide symporter
medicine.medical_specialty
endocrine system diseases
Physiology
Clinical Biochemistry
[SDV.CAN]Life Sciences [q-bio]/Cancer
Biochemistry
Papillary thyroid cancer
Thyroid carcinoma
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Internal medicine
medicine
Molecular Biology
ComputingMilieux_MISCELLANEOUS
General Environmental Science
NADPH oxidase
biology
Chemistry
Thyroid
NOX4
Cell Biology
medicine.disease
030104 developmental biology
Endocrinology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Symporter
biology.protein
Cancer research
General Earth and Planetary Sciences
Subjects
Details
- ISSN :
- 15577716 and 15230864
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Antioxidants & Redox Signaling
- Accession number :
- edsair.doi.dedup.....1c60169a64deaa4989e7d3376d733d60