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Cytotoxic Hexacyclic Triterpene Acids from Euscaphis japonica
- Source :
- Journal of Natural Products. 73:1655-1658
- Publication Year :
- 2010
- Publisher :
- American Chemical Society (ACS), 2010.
-
Abstract
- Six hexacyclic triterpene acids (1-6), named euscaphic acids A-F, and eight known triterpene acid compounds (7-14) were isolated from an ethanolic extract of twigs of Euscaphis japonica. Compounds 8 and 10 were isolated for the first time from a natural source. Triterpenes 1-6 possess hexacyclic skeletons with a 13α,27-cyclopropane ring. Structural elucidation of compounds 1-6 was established by spectroscopic methods, especially 2D NMR techniques ((1)H-(1)H COSY, HMQC, HMBC, and NOESY). Compounds 3, 4, and 14 showed significant cytotoxicity against different cancer cell lines [IC50 = 2.54 (NCI-H460), 3.61 (MCF-7), and 3.27 μM (CEM) for 3, 4, and 14, respectively].
- Subjects :
- Stereochemistry
Chemical structure
Carboxylic acid
Taiwan
Pharmaceutical Science
Pharmacognosy
Staphyleaceae
Analytical Chemistry
Terpene
Inhibitory Concentration 50
Magnoliopsida
Triterpene
Drug Discovery
Humans
Nuclear Magnetic Resonance, Biomolecular
Pharmacology
chemistry.chemical_classification
Molecular Structure
biology
Chemistry
Organic Chemistry
biology.organism_classification
Antineoplastic Agents, Phytogenic
Triterpenes
Terpenoid
Complementary and alternative medicine
Molecular Medicine
Drug Screening Assays, Antitumor
HT29 Cells
Two-dimensional nuclear magnetic resonance spectroscopy
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi.dedup.....1c7c0ff594b92357c295d244edab28f8